ID WAPB_NOTSC Reviewed; 75 AA. AC B5G6H5; DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 1. DT 22-FEB-2023, entry version 30. DE RecName: Full=Notewaprin-b; DE Flags: Precursor; OS Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; OC Serpentes; Colubroidea; Elapidae; Acanthophiinae; Notechis. OX NCBI_TaxID=70142; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC TISSUE=Venom gland; RX PubMed=18979207; DOI=10.1007/s00018-008-8573-5; RA St Pierre L., Earl S.T., Filippovich I., Sorokina N., Masci P.P., RA De Jersey J., Lavin M.F.; RT "Common evolution of waprin and Kunitz-like toxin families in Australian RT venomous snakes."; RL Cell. Mol. Life Sci. 65:4039-4054(2008). CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic CC activity. Not toxic to mice. Does not inhibit the proteinases elastase CC and cathepsin G. {ECO:0000250|UniProtKB:P83952}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ917565; ABK63594.1; -; mRNA. DR EMBL; EU401826; ACC77775.1; -; Genomic_DNA. DR AlphaFoldDB; B5G6H5; -. DR SMR; B5G6H5; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF81; WAP FOUR-DISULFIDE CORE DOMAIN 2; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 1. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal. FT SIGNAL 1..24 FT /evidence="ECO:0000255" FT CHAIN 25..75 FT /note="Notewaprin-b" FT /id="PRO_5000395575" FT DOMAIN 27..72 FT /note="WAP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..60 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 43..64 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 47..59 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 53..68 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" SQ SEQUENCE 75 AA; 8434 MW; 8298713D2A2D35DA CRC64; MSSGGLLLLL GLLTLWAELT PVSSQDRPKK PGLCPPRPQK PPCVRECKND WICPGEQKCC RYGCIYECRD PIFVK //