ID WAPB_NOTSC Reviewed; 75 AA. AC B5G6H5; DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 1. DT 25-OCT-2017, entry version 26. DE RecName: Full=Notewaprin-b; DE Flags: Precursor; OS Notechis scutatus scutatus (Mainland tiger snake) (Common tiger OS snake). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Acanthophiinae; OC Notechis. OX NCBI_TaxID=70142; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC TISSUE=Venom gland; RX PubMed=18979207; DOI=10.1007/s00018-008-8573-5; RA St Pierre L., Earl S.T., Filippovich I., Sorokina N., Masci P.P., RA De Jersey J., Lavin M.F.; RT "Common evolution of waprin and Kunitz-like toxin families in RT Australian venomous snakes."; RL Cell. Mol. Life Sci. 65:4039-4054(2008). CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no CC hemolytic activity. Not toxic to mice. Does not inhibit the CC proteinases elastase and cathepsin G. CC {ECO:0000250|UniProtKB:P83952}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ917565; ABK63594.1; -; mRNA. DR EMBL; EU401826; ACC77775.1; -; Genomic_DNA. DR SMR; B5G6H5; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 1. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 75 Notewaprin-b. FT /FTId=PRO_5000395575. FT DOMAIN 27 72 WAP. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 60 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 43 64 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 47 59 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 53 68 {ECO:0000255|PROSITE-ProRule:PRU00722}. SQ SEQUENCE 75 AA; 8434 MW; 8298713D2A2D35DA CRC64; MSSGGLLLLL GLLTLWAELT PVSSQDRPKK PGLCPPRPQK PPCVRECKND WICPGEQKCC RYGCIYECRD PIFVK //