ID WAPB_NOTSC Reviewed; 75 AA. AC B5G6H5; DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 1. DT 06-MAR-2013, entry version 13. DE RecName: Full=Notewaprin-b; DE Flags: Precursor; OS Notechis scutatus scutatus (Mainland tiger snake) (Common tiger OS snake). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; OC Elapidae; Acanthophiinae; Notechis. OX NCBI_TaxID=70142; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC TISSUE=Venom gland; RX PubMed=18979207; DOI=10.1007/s00018-008-8573-5; RA St Pierre L., Earl S.T., Filippovich I., Sorokina N., Masci P.P., RA De Jersey J., Lavin M.F.; RT "Common evolution of waprin and Kunitz-like toxin families in RT Australian venomous snakes."; RL Cell. Mol. Life Sci. 65:4039-4054(2008). CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no CC hemolytic activity. Not toxic to mice. Does not inhibit the CC proteinases elastase and cathepsin G (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- SIMILARITY: Belongs to the snake waprin family. CC -!- SIMILARITY: Contains 1 WAP domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ917565; ABK63594.1; -; mRNA. DR EMBL; EU401826; ACC77775.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:GOC. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 1. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal. FT SIGNAL 1 24 Potential. FT CHAIN 25 75 Notewaprin-b. FT /FTId=PRO_5000395575. FT DOMAIN 27 72 WAP. FT DISULFID 34 60 By similarity. FT DISULFID 43 64 By similarity. FT DISULFID 47 59 By similarity. FT DISULFID 53 68 By similarity. SQ SEQUENCE 75 AA; 8434 MW; 8298713D2A2D35DA CRC64; MSSGGLLLLL GLLTLWAELT PVSSQDRPKK PGLCPPRPQK PPCVRECKND WICPGEQKCC RYGCIYECRD PIFVK //