ID ARL3_TAEGU Reviewed; 182 AA. AC B5FYQ0; DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 1. DT 07-JAN-2015, entry version 42. DE RecName: Full=ADP-ribosylation factor-like protein 3; GN Name=ARL3; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia; OC Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; OC Passeroidea; Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=17018643; DOI=10.1073/pnas.0607098103; RA Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V., RA Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., RA Zhao S., Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., RA Skene P., Hayashizaki Y., Carninci P., Jarvis E.D.; RT "A molecular neuroethological approach for identifying and RT characterizing a cascade of behaviorally regulated genes."; RL Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006). CC -!- FUNCTION: Small GTP-binding protein which cycles between an CC inactive GDP-bound and an active GTP-bound form, and the rate of CC cycling is regulated by guanine nucleotide exchange factors (GEF) CC and GTPase-activating proteins (GAP). Required for normal CC cytokinesis and cilia signaling. Required for targeting proteins CC to the ciliary membrane by releasing myristoylated protein from CC unc119 cargo adapters into the cilium (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. CC Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule CC organizing center, centrosome {ECO:0000250}. Cytoplasm CC {ECO:0000250}. Cell projection, cilium {ECO:0000250}. CC Note=Detected predominantly in the photoreceptor connecting CC cilium. Centrosome-associated throughout the cell cycle. Not CC detected to interphase microtubules. Present on the mitotic CC spindle (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ214094; ACH44161.1; -; mRNA. DR EMBL; DQ214098; ACH44164.1; -; mRNA. DR UniGene; Tgu.10663; -. DR ProteinModelPortal; B5FYQ0; -. DR STRING; 59729.ENSTGUP00000010506; -. DR PRIDE; B5FYQ0; -. DR eggNOG; COG1100; -. DR HOGENOM; HOG000163691; -. DR HOVERGEN; HBG002073; -. DR InParanoid; B5FYQ0; -. DR Proteomes; UP000007754; Unplaced. DR GO; GO:0005813; C:centrosome; ISS:UniProtKB. DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB. DR GO; GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030496; C:midbody; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0032391; C:photoreceptor connecting cilium; ISS:UniProtKB. DR GO; GO:0072372; C:primary cilium; ISS:UniProtKB. DR GO; GO:0005876; C:spindle microtubule; ISS:UniProtKB. DR GO; GO:0019003; F:GDP binding; ISS:UniProtKB. DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB. DR GO; GO:0003924; F:GTPase activity; ISS:UniProtKB. DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB. DR GO; GO:0060271; P:cilium morphogenesis; ISS:UniProtKB. DR GO; GO:0000910; P:cytokinesis; ISS:UniProtKB. DR GO; GO:0042073; P:intraciliary transport; IEA:Ensembl. DR GO; GO:0001822; P:kidney development; ISS:UniProtKB. DR GO; GO:0042461; P:photoreceptor cell development; ISS:UniProtKB. DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Ensembl. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0007264; P:small GTPase mediated signal transduction; ISS:UniProtKB. DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR024156; Small_GTPase_ARF. DR InterPro; IPR006689; Small_GTPase_ARF/SAR. DR Pfam; PF00025; Arf; 1. DR PRINTS; PR00328; SAR1GTPBP. DR SMART; SM00177; ARF; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. DR PROSITE; PS51417; ARF; 1. PE 2: Evidence at transcript level; KW Cell cycle; Cell division; Cell projection; Complete proteome; KW Cytoplasm; Cytoskeleton; Golgi apparatus; GTP-binding; Lipoprotein; KW Membrane; Myristate; Nucleotide-binding; Nucleus; Protein transport; KW Reference proteome; Transport. FT INIT_MET 1 1 Removed. {ECO:0000255}. FT CHAIN 2 182 ADP-ribosylation factor-like protein 3. FT /FTId=PRO_0000356299. FT NP_BIND 24 31 GTP. {ECO:0000250}. FT NP_BIND 67 71 GTP. {ECO:0000250}. FT NP_BIND 126 129 GTP. {ECO:0000250}. FT LIPID 2 2 N-myristoyl glycine. {ECO:0000255}. SQ SEQUENCE 182 AA; 20442 MW; 67FE4D6F5184F881 CRC64; MGLLSILRKL KSTPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG FKLNVWDIGG QRKIRPYWRN YFENTDILIY VIDSADRKRF EETGQELAEL LDEEKLSGVP VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LSGEGVQDGM NWVCKNVSTK KK //