ID ARL3_TAEGU Reviewed; 182 AA. AC B5FYQ0; DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 1. DT 27-JUL-2011, entry version 20. DE RecName: Full=ADP-ribosylation factor-like protein 3; GN Name=ARL3; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; OC Neognathae; Passeriformes; Passeroidea; Estrildidae; Estrildinae; OC Taeniopygia. OX NCBI_TaxID=59729; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=17018643; DOI=10.1073/pnas.0607098103; RA Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V., RA Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., RA Zhao S., Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., RA Skene P., Hayashizaki Y., Carninci P., Jarvis E.D.; RT "A molecular neuroethological approach for identifying and RT characterizing a cascade of behaviorally regulated genes."; RL Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006). CC -!- FUNCTION: Small GTP-binding protein which cycles between an CC inactive GDP-bound and an active GTP-bound form, and the rate of CC cycling is regulated by guanine nucleotide exchange factors (GEF) CC and GTPase-activating proteins (GAP). Required for normal CC cytokinesis (By similarity). CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane (By similarity); CC Peripheral membrane protein (By similarity); Cytoplasmic side (By CC similarity). Cytoplasm, cytoskeleton, spindle (By similarity). CC Nucleus (By similarity). Cytoplasm, cytoskeleton, centrosome (By CC similarity). Cytoplasm (By similarity). Cell projection, cilium CC (By similarity). Note=Detected predominantly in the photoreceptor CC connecting cilium. Centrosome-associated throughout the cell CC cycle. Not detected to interphase microtubules. Present on the CC mitotic spindle (By similarity). CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ214094; ACH44161.1; -; mRNA. DR EMBL; DQ214098; ACH44164.1; -; mRNA. DR UniGene; Tgu.10663; -. DR ProteinModelPortal; B5FYQ0; -. DR Ensembl; ENSTGUT00000010616; ENSTGUP00000010506; ENSTGUG00000010164. DR GeneTree; ENSGT00600000084074; -. DR HOVERGEN; HBG002073; -. DR OrthoDB; EOG418BPH; -. DR GO; GO:0005813; C:centrosome; ISS:UniProtKB. DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030496; C:midbody; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0032391; C:photoreceptor connecting cilium; ISS:UniProtKB. DR GO; GO:0005876; C:spindle microtubule; ISS:UniProtKB. DR GO; GO:0019003; F:GDP binding; ISS:UniProtKB. DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB. DR GO; GO:0003924; F:GTPase activity; ISS:UniProtKB. DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0000910; P:cytokinesis; ISS:UniProtKB. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR006689; Small_GTPase_ARF/SAR. DR PANTHER; PTHR11711; ARF/SAR; 1. DR Pfam; PF00025; Arf; 1. DR PRINTS; PR00328; SAR1GTPBP. DR TIGRFAMs; TIGR00231; Small_GTP; 1. DR PROSITE; PS51417; ARF; 1. PE 2: Evidence at transcript level; KW Cell cycle; Cell division; Cell projection; Cytoplasm; Cytoskeleton; KW Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Myristate; KW Nucleotide-binding; Nucleus. FT INIT_MET 1 1 Removed (Potential). FT CHAIN 2 182 ADP-ribosylation factor-like protein 3. FT /FTId=PRO_0000356299. FT NP_BIND 24 31 GTP (By similarity). FT NP_BIND 67 71 GTP (By similarity). FT NP_BIND 126 129 GTP (By similarity). FT LIPID 2 2 N-myristoyl glycine (Potential). SQ SEQUENCE 182 AA; 20442 MW; 67FE4D6F5184F881 CRC64; MGLLSILRKL KSTPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG FKLNVWDIGG QRKIRPYWRN YFENTDILIY VIDSADRKRF EETGQELAEL LDEEKLSGVP VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LSGEGVQDGM NWVCKNVSTK KK //