ID B4ZYU4_HBV Unreviewed; 400 AA. AC B4ZYU4; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 01-OCT-2014, entry version 24. DE RecName: Full=Large envelope protein {ECO:0000256|RuleBase:RU003356}; GN Name=S {ECO:0000313|EMBL:ACG68641.1}; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACG68641.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:ACG68641.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=114 {ECO:0000313|EMBL:ACG68641.1}; RA Sun X.-F., Zhang Y.-X., Hou J.-L., Wang Z.-H.; RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The middle envelope protein plays an important role in CC the budding of the virion. It is involved in the induction of CC budding in a nucleocapsid independent way. In this process the CC majority of envelope proteins bud to form subviral lipoprotein CC particles of 22 nm of diameter that do not contain a nucleocapsid. CC {ECO:0000256|SAAS:SAAS00138127}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00138279}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU787435; ACG68641.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 4: Predicted; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00138109}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00138140}; KW Membrane {ECO:0000256|SAAS:SAAS00138112}; KW Transmembrane {ECO:0000256|SAAS:SAAS00138120}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00138067}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00138246}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00138255}; KW Virion {ECO:0000256|SAAS:SAAS00138122}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00138076}. SQ SEQUENCE 400 AA; 43729 MW; 5D49ED7A8C87B4DA CRC64; MGGWSSKPRQ GMGTNLSVPN PLGFFPDHQL DPAFGANSNN PDWDFNPNKD HWPEANQVGV GAFGPGFTPP HGGLLGWSPQ AQGILTAVPA APPPASTNRQ SGRQPTPISP PLRDSHPQAT QWNSTTFLQT LQDPRVRGLY FPAGGSSSGT VNPVPTTVSP ISSIFSRIGD PAPNMENITS GFLGPLLVLQ AGFFLLTRIL TIPQSLDSWW TSLNFLGGTT VCLGQNSQSP TSNHSPTSCP PTCPGYRWMC LRRFIIFLFI LLLCLIFLLV LLDYQGMLPV CPLIPGSPTT STGPCRTCTT PAQGTSMYPS CCCTKPLDGN CTCIPIPSSW AFGKFLWEWA SARFSWLSLL VPFVQWFVGL SPTVWLSVIW MMWYWGPSLY SILSPFLPLL PIFFCLWVYI //