ID B4ZYU4_HBV Unreviewed; 400 AA. AC B4ZYU4; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 08-FEB-2011, entry version 11. DE SubName: Full=Large S protein; GN Name=S; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=114; RA Sun X.-F., Zhang Y.-X., Hou J.-L., Wang Z.-H.; RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The large envelope protein exists in two topological CC conformations, one which is termed 'external' or Le-HBsAg and the CC other 'internal' or Li-HBsAg. In its external conformation the CC protein attaches the virus to cell receptors and thereby CC initiating infection. This interaction determines the species CC specificity and liver tropism. It also assume fusion between CC virion membrane and cellular membrane. In its internal CC conformation the protein plays a role in virion morphogenesis and CC mediates the contact with the nucleocapsid like a matrix protein CC (By similarity). CC -!- FUNCTION: The middle envelope protein plays an important role in CC the budding of the virion. It is involved in the induction of CC budding in a nucleocapsid independent way. In this process the CC majority of envelope proteins bud to form subviral lipoprotein CC particles of 22 nm of diameter that do not contain a nucleocapsid CC (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU787435; ACG68641.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0016032; P:viral reproduction; IEA:InterPro. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 3: Inferred from homology; KW Membrane; Transmembrane; Virion. SQ SEQUENCE 400 AA; 43729 MW; 5D49ED7A8C87B4DA CRC64; MGGWSSKPRQ GMGTNLSVPN PLGFFPDHQL DPAFGANSNN PDWDFNPNKD HWPEANQVGV GAFGPGFTPP HGGLLGWSPQ AQGILTAVPA APPPASTNRQ SGRQPTPISP PLRDSHPQAT QWNSTTFLQT LQDPRVRGLY FPAGGSSSGT VNPVPTTVSP ISSIFSRIGD PAPNMENITS GFLGPLLVLQ AGFFLLTRIL TIPQSLDSWW TSLNFLGGTT VCLGQNSQSP TSNHSPTSCP PTCPGYRWMC LRRFIIFLFI LLLCLIFLLV LLDYQGMLPV CPLIPGSPTT STGPCRTCTT PAQGTSMYPS CCCTKPLDGN CTCIPIPSSW AFGKFLWEWA SARFSWLSLL VPFVQWFVGL SPTVWLSVIW MMWYWGPSLY SILSPFLPLL PIFFCLWVYI //