ID NUDC_SALHS Reviewed; 257 AA. AC B4TCT5; DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 13-NOV-2013, entry version 34. DE RecName: Full=NADH pyrophosphatase; DE EC=3.6.1.22; GN Name=nudC; OrderedLocusNames=SeHA_C4497; OS Salmonella heidelberg (strain SL476). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=454169; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SL476; RA Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., RA Leclerc J., Cebula T., Sebastian Y.; RT "Complete genome of Salmonella heidelberg strain SL476."; RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN. CC -!- COFACTOR: Divalent metal cations. Magnesium or manganese (By CC similarity). CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily. CC -!- SIMILARITY: Contains 1 nudix hydrolase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001120; ACF66801.1; -; Genomic_DNA. DR RefSeq; YP_002048151.1; NC_011083.1. DR ProteinModelPortal; B4TCT5; -. DR STRING; 454169.SeHA_C4497; -. DR EnsemblBacteria; ACF66801; ACF66801; SeHA_C4497. DR KEGG; seh:SeHA_C4497; -. DR PATRIC; 18516431; VBISalEnt43179_4260. DR eggNOG; COG2816; -. DR HOGENOM; HOG000247937; -. DR KO; K03426; -. DR OMA; ACLCHHC; -. DR OrthoDB; EOG6S26JD; -. DR ProtClustDB; PRK00241; -. DR BioCyc; SENT454169:GHYG-4466-MONOMER; -. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP. DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP. DR GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP. DR Gene3D; 3.90.79.10; -; 1. DR HAMAP; MF_00297; Nudix_NudC; 1; -. DR InterPro; IPR022925; NADH_pyroPase_NudC. DR InterPro; IPR020084; NUDIX_hydrolase_CS. DR InterPro; IPR000086; NUDIX_hydrolase_dom. DR InterPro; IPR015797; NUDIX_hydrolase_dom-like. DR InterPro; IPR015376; Znr_NADH_PPase. DR Pfam; PF00293; NUDIX; 1. DR Pfam; PF09297; zf-NADH-PPase; 1. DR SUPFAM; SSF55811; SSF55811; 2. DR PROSITE; PS51462; NUDIX; 1. DR PROSITE; PS00893; NUDIX_BOX; 1. PE 3: Inferred from homology; KW Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; KW NAD; Zinc. FT CHAIN 1 257 NADH pyrophosphatase. FT /FTId=PRO_1000115250. FT DOMAIN 125 248 Nudix hydrolase. FT MOTIF 159 180 Nudix box. FT METAL 98 98 Zinc (By similarity). FT METAL 101 101 Zinc (By similarity). FT METAL 116 116 Zinc (By similarity). FT METAL 119 119 Zinc (By similarity). FT METAL 174 174 Divalent metal cation (By similarity). FT METAL 178 178 Divalent metal cation (By similarity). SQ SEQUENCE 257 AA; 29635 MW; D8F0B689D0F4555C CRC64; MDRIIEKLES GWWIVSHEQK LWLPYGELPH GLAANFDLVG QRALRIGEWQ GEPVWLVLQH RRHDMGSVRQ VIDQDAGLFQ LAGRGVQLAE FYRSHKFCGY CGHPMHPSKT EWAMLCSHCR ERYYPQIAPC IIVAIRREDS ILLARHVRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GEIVIDPKEL LEANWYRYDD LPLLPPPGTV ARRLIEDTVA MCRAEYD //