ID NAAT1_DROWI Reviewed; 641 AA. AC B4NDL8; DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 22-FEB-2023, entry version 66. DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5}; GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GK25473; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260; RN [1] {ECO:0000312|EMBL:EDW81840.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW81840.1}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium CC cotransporter that promotes absorption of the D isomers of essential CC amino acids. Neutral amino acids are the preferred substrates, CC especially methionine and phenylalanine (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC CC 2.A.22) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH964239; EDW81840.1; -; Genomic_DNA. DR RefSeq; XP_002070854.1; XM_002070818.2. DR AlphaFoldDB; B4NDL8; -. DR SMR; B4NDL8; -. DR STRING; 7260.FBpp0254616; -. DR GlyCosmos; B4NDL8; 3 sites, No reported glycans. DR EnsemblMetazoa; FBtr0256124; FBpp0254616; FBgn0227432. DR GeneID; 6648386; -. DR KEGG; dwi:6648386; -. DR eggNOG; KOG3660; Eukaryota. DR HOGENOM; CLU_006855_9_5_1; -. DR InParanoid; B4NDL8; -. DR OMA; WIYGLQN; -. DR OrthoDB; 3084493at2759; -. DR PhylomeDB; B4NDL8; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IC:UniProtKB. DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB. DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0015175; F:neutral L-amino acid transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB. DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB. DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB. DR CDD; cd10324; SLC6sbd; 1. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR037272; SNS_sf. DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1. DR PANTHER; PTHR11616:SF241; TRANSPORTER; 1. DR Pfam; PF00209; SNF; 1. DR PRINTS; PR00176; NANEUSMPORT. DR SUPFAM; SSF161070; SNF-like; 1. DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1. DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 3: Inferred from homology; KW Amino-acid transport; Glycoprotein; Ion transport; Membrane; KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..641 FT /note="Sodium-dependent nutrient amino acid transporter 1" FT /id="PRO_0000386589" FT TOPO_DOM 1..38 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 39..59 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TRANSMEM 72..92 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TRANSMEM 125..145 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TRANSMEM 229..249 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TRANSMEM 258..278 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TRANSMEM 307..327 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TRANSMEM 341..361 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TRANSMEM 401..421 FT /note="Helical; Name=8" FT /evidence="ECO:0000255" FT TRANSMEM 441..461 FT /note="Helical; Name=9" FT /evidence="ECO:0000255" FT TRANSMEM 474..494 FT /note="Helical; Name=10" FT /evidence="ECO:0000255" FT TRANSMEM 516..536 FT /note="Helical; Name=11" FT /evidence="ECO:0000255" FT TRANSMEM 552..572 FT /note="Helical; Name=12" FT /evidence="ECO:0000255" FT REGION 1..37 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..24 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 181 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 190 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 198 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 641 AA; 71796 MW; 6D8C2C9B7CE2D953 CRC64; MELKNIEQQP QLQNGNGTAT ENNEKGEQKP TEGGERTNWG NGLEFLMSCI SVSVGLGNVW RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIIGQFT SQGSVKIWSI CPSFLGVGYG QAFATVCIIS YYSSLLALTL YYLFVSFQSV LPWSYCRDEW TNCVNSRPED YSSTMLEAAR NATSSLLIGN ETTSLADNDS VQLQSSSELY FLNVVIKEKL DISDGVGAPD WKLTLALLVS WIVTFLVIMR GVKSSGKAAY FLAIFPYVVL FVLLGRAVTL EGAVDGIIFF LQPQWGELLN PTVWKEAVVQ CFFSLAVSCG PIIMFASYNR FDHSIYRDAM IVTTLDTLTS LLGGITIFAI LGNLAHNLQV DNIREVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA LQSTIVTIIC DQFKSWKYWK VALVTSICGF LLGLVYVTPG GQWILTLVDF YGGTYVVFIL AIFELAGIVW IYGLQNFCDD IEFMCNKRVS LYWRVCWSFF TPVMMIIIFI YSMATIEPLK YSDLYFPLAG DIAGWIVFAI GTAQFPLWGI WYISHHRNGN LWQSFVSCLK PNENWGPANP ETKQAWLLFK SEKARQRASK TQSSKMGQFW QKVGNFCGSS T //