ID   NAAT1_DROWI             Reviewed;         641 AA.
AC   B4NDL8;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   10-MAY-2017, entry version 45.
DE   RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN   Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GK25473;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW81840.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW81840.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC       cotransporter that promotes absorption of the D isomers of
CC       essential amino acids. Neutral amino acids are the preferred
CC       substrates, especially methionine and phenylalanine (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF)
CC       (TC 2.A.22) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH964239; EDW81840.1; -; Genomic_DNA.
DR   RefSeq; XP_002070854.1; XM_002070818.2.
DR   ProteinModelPortal; B4NDL8; -.
DR   STRING; 7260.FBpp0254616; -.
DR   EnsemblMetazoa; FBtr0256124; FBpp0254616; FBgn0227432.
DR   GeneID; 6648386; -.
DR   KEGG; dwi:Dwil_GK25473; -.
DR   FlyBase; FBgn0227432; Dwil\GK25473.
DR   eggNOG; KOG3660; Eukaryota.
DR   eggNOG; COG0733; LUCA.
DR   InParanoid; B4NDL8; -.
DR   KO; K05038; -.
DR   OMA; WYISRHP; -.
DR   OrthoDB; EOG091G08PX; -.
DR   PhylomeDB; B4NDL8; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR   GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR   GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005283; F:sodium:amino acid symporter activity; ISS:UniProtKB.
DR   GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR   GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Complete proteome; Glycoprotein; Ion transport;
KW   Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    641       Sodium-dependent nutrient amino acid
FT                                transporter 1.
FT                                /FTId=PRO_0000386589.
FT   TOPO_DOM      1     38       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     39     59       Helical; Name=1. {ECO:0000255}.
FT   TRANSMEM     72     92       Helical; Name=2. {ECO:0000255}.
FT   TRANSMEM    125    145       Helical; Name=3. {ECO:0000255}.
FT   TRANSMEM    229    249       Helical; Name=4. {ECO:0000255}.
FT   TRANSMEM    258    278       Helical; Name=5. {ECO:0000255}.
FT   TRANSMEM    307    327       Helical; Name=6. {ECO:0000255}.
FT   TRANSMEM    341    361       Helical; Name=7. {ECO:0000255}.
FT   TRANSMEM    401    421       Helical; Name=8. {ECO:0000255}.
FT   TRANSMEM    441    461       Helical; Name=9. {ECO:0000255}.
FT   TRANSMEM    474    494       Helical; Name=10. {ECO:0000255}.
FT   TRANSMEM    516    536       Helical; Name=11. {ECO:0000255}.
FT   TRANSMEM    552    572       Helical; Name=12. {ECO:0000255}.
FT   CARBOHYD    181    181       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    190    190       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    198    198       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   641 AA;  71796 MW;  6D8C2C9B7CE2D953 CRC64;
     MELKNIEQQP QLQNGNGTAT ENNEKGEQKP TEGGERTNWG NGLEFLMSCI SVSVGLGNVW
     RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIIGQFT SQGSVKIWSI CPSFLGVGYG
     QAFATVCIIS YYSSLLALTL YYLFVSFQSV LPWSYCRDEW TNCVNSRPED YSSTMLEAAR
     NATSSLLIGN ETTSLADNDS VQLQSSSELY FLNVVIKEKL DISDGVGAPD WKLTLALLVS
     WIVTFLVIMR GVKSSGKAAY FLAIFPYVVL FVLLGRAVTL EGAVDGIIFF LQPQWGELLN
     PTVWKEAVVQ CFFSLAVSCG PIIMFASYNR FDHSIYRDAM IVTTLDTLTS LLGGITIFAI
     LGNLAHNLQV DNIREVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA
     LQSTIVTIIC DQFKSWKYWK VALVTSICGF LLGLVYVTPG GQWILTLVDF YGGTYVVFIL
     AIFELAGIVW IYGLQNFCDD IEFMCNKRVS LYWRVCWSFF TPVMMIIIFI YSMATIEPLK
     YSDLYFPLAG DIAGWIVFAI GTAQFPLWGI WYISHHRNGN LWQSFVSCLK PNENWGPANP
     ETKQAWLLFK SEKARQRASK TQSSKMGQFW QKVGNFCGSS T
//