ID NAAT1_DROWI Reviewed; 641 AA. AC B4NDL8; DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 12-APR-2017, entry version 44. DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5}; GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GK25473; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260; RN [1] {ECO:0000312|EMBL:EDW81840.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW81840.1}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium CC cotransporter that promotes absorption of the D isomers of CC essential amino acids. Neutral amino acids are the preferred CC substrates, especially methionine and phenylalanine (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) CC (TC 2.A.22) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH964239; EDW81840.1; -; Genomic_DNA. DR RefSeq; XP_002070854.1; XM_002070818.2. DR ProteinModelPortal; B4NDL8; -. DR STRING; 7260.FBpp0254616; -. DR EnsemblMetazoa; FBtr0256124; FBpp0254616; FBgn0227432. DR GeneID; 6648386; -. DR KEGG; dwi:Dwil_GK25473; -. DR FlyBase; FBgn0227432; Dwil\GK25473. DR eggNOG; KOG3660; Eukaryota. DR eggNOG; COG0733; LUCA. DR InParanoid; B4NDL8; -. DR KO; K05038; -. DR OMA; WYISRHP; -. DR OrthoDB; EOG091G08PX; -. DR PhylomeDB; B4NDL8; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB. DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa. DR GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0005283; F:sodium:amino acid symporter activity; ISS:UniProtKB. DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB. DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB. DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB. DR InterPro; IPR000175; Na/ntran_symport. DR PANTHER; PTHR11616; PTHR11616; 1. DR Pfam; PF00209; SNF; 1. DR PRINTS; PR00176; NANEUSMPORT. DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1. DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 3: Inferred from homology; KW Amino-acid transport; Complete proteome; Glycoprotein; Ion transport; KW Membrane; Reference proteome; Sodium; Sodium transport; Symport; KW Transmembrane; Transmembrane helix; Transport. FT CHAIN 1 641 Sodium-dependent nutrient amino acid FT transporter 1. FT /FTId=PRO_0000386589. FT TOPO_DOM 1 38 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 39 59 Helical; Name=1. {ECO:0000255}. FT TRANSMEM 72 92 Helical; Name=2. {ECO:0000255}. FT TRANSMEM 125 145 Helical; Name=3. {ECO:0000255}. FT TRANSMEM 229 249 Helical; Name=4. {ECO:0000255}. FT TRANSMEM 258 278 Helical; Name=5. {ECO:0000255}. FT TRANSMEM 307 327 Helical; Name=6. {ECO:0000255}. FT TRANSMEM 341 361 Helical; Name=7. {ECO:0000255}. FT TRANSMEM 401 421 Helical; Name=8. {ECO:0000255}. FT TRANSMEM 441 461 Helical; Name=9. {ECO:0000255}. FT TRANSMEM 474 494 Helical; Name=10. {ECO:0000255}. FT TRANSMEM 516 536 Helical; Name=11. {ECO:0000255}. FT TRANSMEM 552 572 Helical; Name=12. {ECO:0000255}. FT CARBOHYD 181 181 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 190 190 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 198 198 N-linked (GlcNAc...). {ECO:0000255}. SQ SEQUENCE 641 AA; 71796 MW; 6D8C2C9B7CE2D953 CRC64; MELKNIEQQP QLQNGNGTAT ENNEKGEQKP TEGGERTNWG NGLEFLMSCI SVSVGLGNVW RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIIGQFT SQGSVKIWSI CPSFLGVGYG QAFATVCIIS YYSSLLALTL YYLFVSFQSV LPWSYCRDEW TNCVNSRPED YSSTMLEAAR NATSSLLIGN ETTSLADNDS VQLQSSSELY FLNVVIKEKL DISDGVGAPD WKLTLALLVS WIVTFLVIMR GVKSSGKAAY FLAIFPYVVL FVLLGRAVTL EGAVDGIIFF LQPQWGELLN PTVWKEAVVQ CFFSLAVSCG PIIMFASYNR FDHSIYRDAM IVTTLDTLTS LLGGITIFAI LGNLAHNLQV DNIREVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA LQSTIVTIIC DQFKSWKYWK VALVTSICGF LLGLVYVTPG GQWILTLVDF YGGTYVVFIL AIFELAGIVW IYGLQNFCDD IEFMCNKRVS LYWRVCWSFF TPVMMIIIFI YSMATIEPLK YSDLYFPLAG DIAGWIVFAI GTAQFPLWGI WYISHHRNGN LWQSFVSCLK PNENWGPANP ETKQAWLLFK SEKARQRASK TQSSKMGQFW QKVGNFCGSS T //