ID B4N8K5_DROWI Unreviewed; 1910 AA. AC B4N8K5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 30-NOV-2016, entry version 74. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW81456.2}; GN Name=Dwil\GK12078 {ECO:0000313|EMBL:EDW81456.2}; GN ORFNames=Dwil_GK12078 {ECO:0000313|EMBL:EDW81456.2}, GK12078 GN {ECO:0000313|FlyBase:FBgn0214089}; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798}; RN [1] {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a CC [protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00584670}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. {ECO:0000256|SAAS:SAAS00601601}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH964232; EDW81456.2; -; Genomic_DNA. DR RefSeq; XP_002070470.2; XM_002070434.2. DR STRING; 7260.FBpp0241221; -. DR EnsemblMetazoa; FBtr0242729; FBpp0241221; FBgn0214089. DR GeneID; 6647111; -. DR KEGG; dwi:Dwil_GK12078; -. DR FlyBase; FBgn0214089; Dwil\GK12078. DR eggNOG; KOG4258; Eukaryota. DR eggNOG; COG0515; LUCA. DR InParanoid; B4N8K5; -. DR KO; K05087; -. DR OrthoDB; EOG091G014Y; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; -; 4. DR Gene3D; 3.80.20.20; -; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR009030; Growth_fac_rcpt_. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR032675; L_dom-like. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00060; FN3; 3. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF49265; SSF49265; 4. DR SUPFAM; SSF52058; SSF52058; 3. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS50853; FN3; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|SAAS:SAAS00600564}; KW Complete proteome {ECO:0000313|Proteomes:UP000007798}; KW Kinase {ECO:0000256|SAAS:SAAS00601152}; KW Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689}; KW Receptor {ECO:0000256|SAAS:SAAS00600436}; KW Reference proteome {ECO:0000313|Proteomes:UP000007798}; KW Repeat {ECO:0000256|SAAS:SAAS00067853}; KW Transferase {ECO:0000256|SAAS:SAAS00601608}; KW Transmembrane {ECO:0000256|SAAS:SAAS00600943, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00602683, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}. FT TRANSMEM 1058 1081 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 546 653 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 957 1054 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1118 1401 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. SQ SEQUENCE 1910 AA; 211415 MW; 8A5902CD593896E4 CRC64; MIIMSLLAMH ATAAIQLPPS HQQLSSSHHQ YDSNDLGDSL AIFTSSPRIR RDSGNASGNS IGKSGDSGNT QVRLSRNETM CKSMDIRNYA TNFNQLTNCT IIEGFLLITL INDAHLLNTT YPLLTEVTEY IIVYRVNNLL SLSQIFPNLS VIRGNSLFDG YALVVYQNRD LQDIGLSKLR AIANGAVRFE KNLSLCFLTT VDWSQIISKN SSEMVSIENR NPTLCPKCPG EIRLSDDGAN SGSTEADPLS CKKHTDGKRY CWGSRSCQSF CPKECPDNCY DEHTCCNKAC LGGCVRDKNG SLGCISCRYV SIHNNTCLNE CPKDYFLYGR RCITAEMCRS IGTKYESTKE LKLMHFDGQC TTRCPKGFQI EETTNTCVPC NGTCEKRCEG GQIESGGRAR EFYGCTKIGI TNGLVISIKR GGPHIMEDLE YGLAKVHTIE TYLKVHLTYG LSTLAFFKSL RQIRGNVTFE HRYALYVLEN NELEEIWAPN QTVEIANGSV FFHFNPKLCM KTIKTLLPML PSKPTSFEKT EVAGDSNGNK GSCNTTVLNV KIKSQTDSMA LIFVNQSLKF DDLRTFIGYQ SFYTKDPYGN ATKNSYHPCD ESWTASEPVK EDNLMITDLE PYTQYAYYVK TWTISSESQN GLSPIQHFTT LPAQPTLVQK IKARANSSSE IEVQWEPPRS VRGKLKLYLV KAVLTHRDAK LESHQQRNYC WDPLPNNNED NIIVEKAKVT DKQPTDAADC QCNANSGGPS VGVGGKGANF EQNRREEIEF ENALQNFLYV RRQGDQNRTN PAVAPPPKPK DNSIKDDGLL DNAVHKRRRR RRELDFDDDG DDDGDLGMGS VLSRHVRSTE TQDDLRNLYA MDNMGATENA EKIRPETWLK ETRKSADGTY YEILTQQVGA NQTHFVFTNL RHFSLYTISV VACREEVAGS FKPSCGNASP IDKLTRKLEN ADLVANVTAD LESANATRPG VRLRWLAPLN PNGAIVSYTI GYKLQMPDQQ ELMKCVTAQD YLNLTDGYVV KHLSEGNYSF HVRANSMAGD GIFSELVYVV VPPPPTYMIY YIFVGIGIIM SLSGILIFVL YKKKKMTPRD LYINTEVNPF YASHQYIPDD WEVARDCILQ LGPLGQGSFG MVYEGILKGH MGVDTPCAIK TVNENATDRE RVNFLSEASV MKEFDTFHVV HLLGVCSHGQ PALVVMELMK KGDLKSYLRA HRPEERNEEM LAYLQRIGVT GNASPPTYGR FYQMAIEIAD GMAYLSAKKF VHRDLAARNC MVSDDLTVKI GDFGMTRDIY ETDYYRKGTK GLLPVRWMPP ESLRDGVYAS SSDVFSFGVV LWEMATLASQ PYQGLSNEQV LRYVIDGGIM ERPENCPDVL HKLMHRCWHH RPSARPSFLD IIAYLEPHSS NAHFKEVSFY HSEAGLQYRE KDRKEKSQMD AAFVAEPLDQ DHEDATTPLR VGDYQSGYKS NMDQNASLEQ PAESPINIVE EQTAHSPFSL QSGFVVSSTP DAPTAGGISH DDTSGYVQPD ADALASTGAD RGYEIYDPSP NFAELPTSRS GSTGAGGGDG KLSGEQHLLP RKSRRTPIIM SSSMPDDVVS GGAGSLQPST ASAGSSNASS HTGGGSRGTS SLKKIMNRSI LFNRPFFNHK RTGSNASHKS NSSITPSTCS NANLTPHPIA TSNLGTIESG GSGSAGSYAG TPRFYTPAAT PSIGGGGISD NPNYKLLDES IISGGTARSW NQNRGPGTMA AGLSDSEQAT MLTISSLNPN YELMQPPSPT PSLRAYPNYV QMNEPAPVIL SSMNPNYEQM QAPHAHLSSS DEEDLNENDD DCHEDIKMER MPLSRQKPRS QYKSSSQTPR SRSVSQNRKK NDQHTTPQQT ASSAMAAAGN VSNILKENWL RQAASTNRPP PPNGFIGREA //