ID   B4N8K5_DROWI            Unreviewed;      1910 AA.
AC   B4N8K5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   17-FEB-2016, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW81456.2};
GN   Name=Dwil\GK12078 {ECO:0000313|EMBL:EDW81456.2};
GN   ORFNames=Dwil_GK12078 {ECO:0000313|EMBL:EDW81456.2}, GK12078
GN   {ECO:0000313|FlyBase:FBgn0214089};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00316103}.
CC   -!- SIMILARITY: Contains protein kinase domain.
CC       {ECO:0000256|SAAS:SAAS00244010}.
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DR   EMBL; CH964232; EDW81456.2; -; Genomic_DNA.
DR   RefSeq; XP_002070470.1; XM_002070434.1.
DR   STRING; 7260.FBpp0241221; -.
DR   EnsemblMetazoa; FBtr0242729; FBpp0241221; FBgn0214089.
DR   GeneID; 6647111; -.
DR   KEGG; dwi:Dwil_GK12078; -.
DR   FlyBase; FBgn0214089; Dwil\GK12078.
DR   eggNOG; COG0515; LUCA.
DR   eggNOG; KOG4258; Eukaryota.
DR   InParanoid; B4N8K5; -.
DR   KO; K05087; -.
DR   OMA; KDPRAFI; -.
DR   OrthoDB; EOG7B31KZ; -.
DR   PhylomeDB; B4N8K5; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 4.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR032675; L_dom-like.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; SSF49265; 4.
DR   SUPFAM; SSF52058; SSF52058; 3.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00427784};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Kinase {ECO:0000256|SAAS:SAAS00428296};
KW   Membrane {ECO:0000256|SAAS:SAAS00427660, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00428329};
KW   Receptor {ECO:0000256|SAAS:SAAS00428478};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Repeat {ECO:0000256|SAAS:SAAS00461231};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00427885};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00427632,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00427716,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00428043}.
FT   SIGNAL        1     14       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        15   1910       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006458269.
FT   TRANSMEM   1058   1081       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      546    653       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      957   1054       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1118   1401       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   1910 AA;  211415 MW;  8A5902CD593896E4 CRC64;
     MIIMSLLAMH ATAAIQLPPS HQQLSSSHHQ YDSNDLGDSL AIFTSSPRIR RDSGNASGNS
     IGKSGDSGNT QVRLSRNETM CKSMDIRNYA TNFNQLTNCT IIEGFLLITL INDAHLLNTT
     YPLLTEVTEY IIVYRVNNLL SLSQIFPNLS VIRGNSLFDG YALVVYQNRD LQDIGLSKLR
     AIANGAVRFE KNLSLCFLTT VDWSQIISKN SSEMVSIENR NPTLCPKCPG EIRLSDDGAN
     SGSTEADPLS CKKHTDGKRY CWGSRSCQSF CPKECPDNCY DEHTCCNKAC LGGCVRDKNG
     SLGCISCRYV SIHNNTCLNE CPKDYFLYGR RCITAEMCRS IGTKYESTKE LKLMHFDGQC
     TTRCPKGFQI EETTNTCVPC NGTCEKRCEG GQIESGGRAR EFYGCTKIGI TNGLVISIKR
     GGPHIMEDLE YGLAKVHTIE TYLKVHLTYG LSTLAFFKSL RQIRGNVTFE HRYALYVLEN
     NELEEIWAPN QTVEIANGSV FFHFNPKLCM KTIKTLLPML PSKPTSFEKT EVAGDSNGNK
     GSCNTTVLNV KIKSQTDSMA LIFVNQSLKF DDLRTFIGYQ SFYTKDPYGN ATKNSYHPCD
     ESWTASEPVK EDNLMITDLE PYTQYAYYVK TWTISSESQN GLSPIQHFTT LPAQPTLVQK
     IKARANSSSE IEVQWEPPRS VRGKLKLYLV KAVLTHRDAK LESHQQRNYC WDPLPNNNED
     NIIVEKAKVT DKQPTDAADC QCNANSGGPS VGVGGKGANF EQNRREEIEF ENALQNFLYV
     RRQGDQNRTN PAVAPPPKPK DNSIKDDGLL DNAVHKRRRR RRELDFDDDG DDDGDLGMGS
     VLSRHVRSTE TQDDLRNLYA MDNMGATENA EKIRPETWLK ETRKSADGTY YEILTQQVGA
     NQTHFVFTNL RHFSLYTISV VACREEVAGS FKPSCGNASP IDKLTRKLEN ADLVANVTAD
     LESANATRPG VRLRWLAPLN PNGAIVSYTI GYKLQMPDQQ ELMKCVTAQD YLNLTDGYVV
     KHLSEGNYSF HVRANSMAGD GIFSELVYVV VPPPPTYMIY YIFVGIGIIM SLSGILIFVL
     YKKKKMTPRD LYINTEVNPF YASHQYIPDD WEVARDCILQ LGPLGQGSFG MVYEGILKGH
     MGVDTPCAIK TVNENATDRE RVNFLSEASV MKEFDTFHVV HLLGVCSHGQ PALVVMELMK
     KGDLKSYLRA HRPEERNEEM LAYLQRIGVT GNASPPTYGR FYQMAIEIAD GMAYLSAKKF
     VHRDLAARNC MVSDDLTVKI GDFGMTRDIY ETDYYRKGTK GLLPVRWMPP ESLRDGVYAS
     SSDVFSFGVV LWEMATLASQ PYQGLSNEQV LRYVIDGGIM ERPENCPDVL HKLMHRCWHH
     RPSARPSFLD IIAYLEPHSS NAHFKEVSFY HSEAGLQYRE KDRKEKSQMD AAFVAEPLDQ
     DHEDATTPLR VGDYQSGYKS NMDQNASLEQ PAESPINIVE EQTAHSPFSL QSGFVVSSTP
     DAPTAGGISH DDTSGYVQPD ADALASTGAD RGYEIYDPSP NFAELPTSRS GSTGAGGGDG
     KLSGEQHLLP RKSRRTPIIM SSSMPDDVVS GGAGSLQPST ASAGSSNASS HTGGGSRGTS
     SLKKIMNRSI LFNRPFFNHK RTGSNASHKS NSSITPSTCS NANLTPHPIA TSNLGTIESG
     GSGSAGSYAG TPRFYTPAAT PSIGGGGISD NPNYKLLDES IISGGTARSW NQNRGPGTMA
     AGLSDSEQAT MLTISSLNPN YELMQPPSPT PSLRAYPNYV QMNEPAPVIL SSMNPNYEQM
     QAPHAHLSSS DEEDLNENDD DCHEDIKMER MPLSRQKPRS QYKSSSQTPR SRSVSQNRKK
     NDQHTTPQQT ASSAMAAAGN VSNILKENWL RQAASTNRPP PPNGFIGREA
//