ID   B4N8K5_DROWI            Unreviewed;      1984 AA.
AC   B4N8K5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   25-JAN-2012, entry version 32.
DE   SubName: Full=GK12078;
GN   Name=GK12078; Synonyms=Dwil\GK12078; ORFNames=Dwil_GK12078;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; CH964232; EDW81456.1; -; Genomic_DNA.
DR   RefSeq; XP_002070470.1; XM_002070434.1.
DR   STRING; B4N8K5; -.
DR   EnsemblMetazoa; FBtr0242729; FBpp0241221; FBgn0214089.
DR   GeneID; 6647111; -.
DR   KEGG; dwi:Dwil_GK12078; -.
DR   FlyBase; FBgn0214089; Dwil\GK12078.
DR   GeneTree; EMGT00050000002732; -.
DR   InParanoid; B4N8K5; -.
DR   OMA; NASSHTG; -.
DR   OrthoDB; EOG4TB2S5; -.
DR   PhylomeDB; B4N8K5; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   InterPro; IPR000494; EGF_rcpt_L.
DR   InterPro; IPR003961; Fibronectin_type3.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR020713; Insulin-like_rcpt_insect.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 4.
DR   PANTHER; PTHR24416:SF179; PTHR24416:SF179; 1.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00261; FU; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; FN_III-like; 2.
DR   SUPFAM; SSF57184; Grow_fac_recept; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   4: Predicted;
KW   ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Receptor; Transferase; Transmembrane;
KW   Transmembrane helix; Tyrosine-protein kinase.
SQ   SEQUENCE   1984 AA;  220997 MW;  435A411884214367 CRC64;
     MLELPQQFEE ICAITKTRAF YRLNIWKTKQ PYNKHNQQQQ QQLVSNCATS QQQQQQQRQR
     HQQQQHCYQH YNQQQHLRQQ LSHHHQHQQQ QQQHQHRHHH RHNWKSNLAL MIIMSLLAMH
     ATAAIQLPPS HQQLSSSHHQ YDSNDLGDSL AIFTSSPRIR RDSGNASGNS IGKSGDSGNT
     QVRLSRNETM CKSMDIRNYA TNFNQLTNCT IIEGFLLITL INDAHLLNTT YPLLTEVTEY
     IIVYRVNNLL SLSQIFPNLS VIRGNSLFDG YALVVYQNRD LQDIGLSKLR AIANGAVRFE
     KNLSLCFLTT VDWSQIISKN SSEMVSIENR NPTLCPKCPG EIRLSDDGAN SGSTEADPLS
     CKKHTDGKRY CWGSRSCQSF CPKECPDNCY DEHTCCNKAC LGGCVRDKNG SLGCISCRYV
     SIHNNTCLNE CPKDYFLYGR RCITAEMCRS IGTKYESTKE LKLMHFDGQC TTRCPKGFQI
     EETTNTCVPC NGTCEKRCEG GQIESGGRAR EFYGCTKIGI TNGLVISIKR GGPHIMEDLE
     YGLAKVHTIE TYLKVHLTYG LSTLAFFKSL RQIRGNVTFE HRYALYVLEN NELEEIWAPN
     QTVEIANGSV FFHFNPKLCM KTIKTLLPML PSKPTSFEKT EVAGDSNGNK GSCNTTVLND
     PYGNATKNSY HPCDESWTAS EPVKEDNLMI TDLEPYTQYA YYVKTWTISS ESQNGLSPIQ
     HFTTLPAQPT LVQKIKARAN SSSEIEVQWE PPRSVRGKLK LYLVKAVLTH RDAKLESHQQ
     RNYCWDPLPN NNEDNIIVEK AKVTDKQPTD AADCQCNANS GGPSVGVGGK GANFEQNRRE
     EIEFENALQN FLYVRRQGDQ NRTNPAVAPP PKPKDNSIKD DGLLDNAVHK RRRRRRELDF
     DDDGDDDGDL GMGSVLSRHV RSTETQDDLR NLYAMDNMGA TENAEKIRPE TWLKETRKSA
     DGTYYEILTQ QVGANQTHFV FTNLRHFSLY TISVVACREE VAGSFKPSCG NASPIDKLTR
     KLENADLVAN VTADLESANA TRPGVRLRWL APLNPNGAIV SYTIGYKLQM PDQQELMKCV
     TAQDYLNLTD GYVVKHLSEG NYSFHVRANS MAGDGIFSEL VYVVVPPPPT YMIYYIFVGI
     GIIMSLSGIL IFVLYKKKKM TPRDLYINTE VNPFYASHQY IPDDWEVARD CILQLGPLGQ
     GSFGMVYEGI LKGHMGVDTP CAIKTVNENA TDRERVNFLS EASVMKEFDT FHVVHLLGVC
     SHGQPALVVM ELMKKGDLKS YLRAHRPEER NEEMLAYLQR IGVTGNASPP TYGRFYQMAI
     EIADGMAYLS AKKFVHRDLA ARNCMVSDDL TVKIGDFGMT RDIYETDYYR KGTKGLLPVR
     WMPPESLRDG VYASSSDVFS FGVVLWEMAT LASQPYQGLS NEQVLRYVID GGIMERPENC
     PDVLHKLMHR CWHHRPSARP SFLDIIAYLE PHSSNAHFKE VSFYHSEAGL QYREKDRKEK
     SQMDAAFVAE PLDQDHEDAT TPLRVGDYQS GYKSNMDQNA SLEQPAESPI NIVEEQTAHS
     PFSLQSGFVV SSTPDAPTAG GISHDDTSGY VQPDADALAS TGADRGYEIY DPSPNFAELP
     TSRSGSTGAG GGDGKLSGEQ HLLPRKSRRT PIIMSSSMPD DVVSGGAGSL QPSTASAGSS
     NASSHTGGGS RGTSSLKKIM NRSILFNRPF FNHKRTGSNA SHKSNSSITP STCSNANLTP
     HPIATSNLGT IESGGSGSAG SYAGTPRFYT PAATPSIGGG GISDNPNYKL LDESIISGGT
     ARSWNQNRGP GTMAAGLSDS EQATMLTISS LNPNYELMQP PSPTPSLRAY PNYVQMNEPA
     PVILSSMNPN YEQMQAPHAH LSSSDEEDLN ENDDDCHEDI KMERMPLSRQ KPRSQYKSSS
     QTPRSRSVSQ NRKKNDQHTT PQQTASSAMA AAGNVSNILK ENWLRQAAST NRPPPPNGFI
     GREA
//