ID B4N8K5_DROWI Unreviewed; 1910 AA. AC B4N8K5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 19-JAN-2022, entry version 111. DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902}; GN Name=Dwil\GK12078 {ECO:0000313|EMBL:EDW81456.2}; GN ORFNames=Dwil_GK12078 {ECO:0000313|EMBL:EDW81456.2}; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798}; RN [1] {ECO:0000313|EMBL:EDW81456.2, ECO:0000313|Proteomes:UP000007798} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M., RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH964232; EDW81456.2; -; Genomic_DNA. DR RefSeq; XP_002070470.2; XM_002070434.2. DR SMR; B4N8K5; -. DR STRING; 7260.FBpp0241221; -. DR EnsemblMetazoa; FBtr0418889; FBpp0377030; FBgn0214089. DR GeneID; 6647111; -. DR KEGG; dwi:6647111; -. DR eggNOG; KOG4258; Eukaryota. DR HOGENOM; CLU_000288_166_2_1; -. DR InParanoid; B4N8K5; -. DR OMA; QYIPDDW; -. DR OrthoDB; 223327at2759; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0005899; C:insulin receptor complex; IEA:EnsemblMetazoa. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa. DR GO; GO:0043559; F:insulin binding; IEA:EnsemblMetazoa. DR GO; GO:0005009; F:insulin-activated receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:RHEA. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa. DR GO; GO:0042632; P:cholesterol homeostasis; IEA:EnsemblMetazoa. DR GO; GO:0007623; P:circadian rhythm; IEA:EnsemblMetazoa. DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa. DR GO; GO:0048132; P:female germ-line stem cell asymmetric division; IEA:EnsemblMetazoa. DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa. DR GO; GO:0008585; P:female gonad development; IEA:EnsemblMetazoa. DR GO; GO:0060180; P:female mating behavior; IEA:EnsemblMetazoa. DR GO; GO:0007390; P:germ-band shortening; IEA:EnsemblMetazoa. DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa. DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa. DR GO; GO:0007446; P:imaginal disc growth; IEA:EnsemblMetazoa. DR GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:EnsemblMetazoa. DR GO; GO:0007626; P:locomotory behavior; IEA:EnsemblMetazoa. DR GO; GO:0048542; P:lymph gland development; IEA:EnsemblMetazoa. DR GO; GO:0048133; P:male germ-line stem cell asymmetric division; IEA:EnsemblMetazoa. DR GO; GO:0035264; P:multicellular organism growth; IEA:EnsemblMetazoa. DR GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa. DR GO; GO:0061964; P:negative regulation of entry into reproductive diapause; IEA:EnsemblMetazoa. DR GO; GO:2000252; P:negative regulation of feeding behavior; IEA:EnsemblMetazoa. DR GO; GO:0090278; P:negative regulation of peptide hormone secretion; IEA:EnsemblMetazoa. DR GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa. DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa. DR GO; GO:0030307; P:positive regulation of cell growth; IEA:EnsemblMetazoa. DR GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa. DR GO; GO:0070346; P:positive regulation of fat cell proliferation; IEA:EnsemblMetazoa. DR GO; GO:0010884; P:positive regulation of lipid storage; IEA:EnsemblMetazoa. DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa. DR GO; GO:1904801; P:positive regulation of neuron remodeling; IEA:EnsemblMetazoa. DR GO; GO:0046622; P:positive regulation of organ growth; IEA:EnsemblMetazoa. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:EnsemblMetazoa. DR GO; GO:0090303; P:positive regulation of wound healing; IEA:EnsemblMetazoa. DR GO; GO:0007285; P:primary spermatocyte growth; IEA:EnsemblMetazoa. DR GO; GO:0046777; P:protein autophosphorylation; IEA:EnsemblMetazoa. DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:EnsemblMetazoa. DR GO; GO:0034059; P:response to anoxia; IEA:EnsemblMetazoa. DR GO; GO:0042220; P:response to cocaine; IEA:EnsemblMetazoa. DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa. DR GO; GO:0070328; P:triglyceride homeostasis; IEA:EnsemblMetazoa. DR CDD; cd00063; FN3; 1. DR CDD; cd00064; FU; 1. DR Gene3D; 2.60.40.10; -; 4. DR Gene3D; 3.80.20.20; -; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR036941; Rcpt_L-dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00060; FN3; 3. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF49265; SSF49265; 3. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS50853; FN3; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000007798}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}. FT TRANSMEM 1058..1081 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 957..1054 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 1118..1401 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 48..70 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 782..848 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1531..1621 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1641..1685 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1801..1820 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1828..1910 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 800..827 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1593..1621 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1837..1899 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 1150 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 1910 AA; 211415 MW; 8A5902CD593896E4 CRC64; MIIMSLLAMH ATAAIQLPPS HQQLSSSHHQ YDSNDLGDSL AIFTSSPRIR RDSGNASGNS IGKSGDSGNT QVRLSRNETM CKSMDIRNYA TNFNQLTNCT IIEGFLLITL INDAHLLNTT YPLLTEVTEY IIVYRVNNLL SLSQIFPNLS VIRGNSLFDG YALVVYQNRD LQDIGLSKLR AIANGAVRFE KNLSLCFLTT VDWSQIISKN SSEMVSIENR NPTLCPKCPG EIRLSDDGAN SGSTEADPLS CKKHTDGKRY CWGSRSCQSF CPKECPDNCY DEHTCCNKAC LGGCVRDKNG SLGCISCRYV SIHNNTCLNE CPKDYFLYGR RCITAEMCRS IGTKYESTKE LKLMHFDGQC TTRCPKGFQI EETTNTCVPC NGTCEKRCEG GQIESGGRAR EFYGCTKIGI TNGLVISIKR GGPHIMEDLE YGLAKVHTIE TYLKVHLTYG LSTLAFFKSL RQIRGNVTFE HRYALYVLEN NELEEIWAPN QTVEIANGSV FFHFNPKLCM KTIKTLLPML PSKPTSFEKT EVAGDSNGNK GSCNTTVLNV KIKSQTDSMA LIFVNQSLKF DDLRTFIGYQ SFYTKDPYGN ATKNSYHPCD ESWTASEPVK EDNLMITDLE PYTQYAYYVK TWTISSESQN GLSPIQHFTT LPAQPTLVQK IKARANSSSE IEVQWEPPRS VRGKLKLYLV KAVLTHRDAK LESHQQRNYC WDPLPNNNED NIIVEKAKVT DKQPTDAADC QCNANSGGPS VGVGGKGANF EQNRREEIEF ENALQNFLYV RRQGDQNRTN PAVAPPPKPK DNSIKDDGLL DNAVHKRRRR RRELDFDDDG DDDGDLGMGS VLSRHVRSTE TQDDLRNLYA MDNMGATENA EKIRPETWLK ETRKSADGTY YEILTQQVGA NQTHFVFTNL RHFSLYTISV VACREEVAGS FKPSCGNASP IDKLTRKLEN ADLVANVTAD LESANATRPG VRLRWLAPLN PNGAIVSYTI GYKLQMPDQQ ELMKCVTAQD YLNLTDGYVV KHLSEGNYSF HVRANSMAGD GIFSELVYVV VPPPPTYMIY YIFVGIGIIM SLSGILIFVL YKKKKMTPRD LYINTEVNPF YASHQYIPDD WEVARDCILQ LGPLGQGSFG MVYEGILKGH MGVDTPCAIK TVNENATDRE RVNFLSEASV MKEFDTFHVV HLLGVCSHGQ PALVVMELMK KGDLKSYLRA HRPEERNEEM LAYLQRIGVT GNASPPTYGR FYQMAIEIAD GMAYLSAKKF VHRDLAARNC MVSDDLTVKI GDFGMTRDIY ETDYYRKGTK GLLPVRWMPP ESLRDGVYAS SSDVFSFGVV LWEMATLASQ PYQGLSNEQV LRYVIDGGIM ERPENCPDVL HKLMHRCWHH RPSARPSFLD IIAYLEPHSS NAHFKEVSFY HSEAGLQYRE KDRKEKSQMD AAFVAEPLDQ DHEDATTPLR VGDYQSGYKS NMDQNASLEQ PAESPINIVE EQTAHSPFSL QSGFVVSSTP DAPTAGGISH DDTSGYVQPD ADALASTGAD RGYEIYDPSP NFAELPTSRS GSTGAGGGDG KLSGEQHLLP RKSRRTPIIM SSSMPDDVVS GGAGSLQPST ASAGSSNASS HTGGGSRGTS SLKKIMNRSI LFNRPFFNHK RTGSNASHKS NSSITPSTCS NANLTPHPIA TSNLGTIESG GSGSAGSYAG TPRFYTPAAT PSIGGGGISD NPNYKLLDES IISGGTARSW NQNRGPGTMA AGLSDSEQAT MLTISSLNPN YELMQPPSPT PSLRAYPNYV QMNEPAPVIL SSMNPNYEQM QAPHAHLSSS DEEDLNENDD DCHEDIKMER MPLSRQKPRS QYKSSSQTPR SRSVSQNRKK NDQHTTPQQT ASSAMAAAGN VSNILKENWL RQAASTNRPP PPNGFIGREA //