ID SG111_DROWI Reviewed; 209 AA. AC B4MVH6; DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 15-JUN-2010, entry version 12. DE RecName: Full=SAGA-associated factor 11 homolog 1; GN Name=Sgf11-1; ORFNames=GK15061; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: Component of the transcription regulatory histone CC acetylation (HAT) complex SAGA, a multiprotein complex that CC activates transcription by remodeling chromatin and mediating CC histone acetylation and deubiquitination. Within the SAGA complex, CC participates to a subcomplex that specifically deubiquitinates CC histone H2B. The SAGA complex is recruited to specific gene CC promoters by activators, where it is required for transcription. CC Required to counteract heterochromatin silencing. Controls the CC development of neuronal connectivity in visual system by being CC required for accurate axon targeting in the optic lobe. Required CC for expression of ecdysone-induced genes such as br/broad (By CC similarity). CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, CC Sgf11 and Spt3. Interacts directly with not/nonstop (By CC similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the SGF11 family. CC -!- SIMILARITY: Contains 1 SGF11-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH963857; EDW75696.1; -; Genomic_DNA. DR RefSeq; XP_002064710.1; -. DR EnsemblMetazoa; FBtr0245712; FBpp0244204; FBgn0217066. DR GeneID; 6642765; -. DR KEGG; dwi:Dwil_GK15061; -. DR FlyBase; FBgn0217066; Dwil\GK15061. DR InParanoid; B4MVH6; -. DR OrthoDB; EOG97WNVT; -. DR GO; GO:0000124; C:SAGA complex; ISS:UniProtKB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016568; P:chromatin modification; ISS:UniProtKB. DR GO; GO:0045893; P:positive regulation of transcription, DNA-d...; ISS:UniProtKB. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR013246; Sgf11. DR Pfam; PF08209; Sgf11; 1. PE 3: Inferred from homology; KW Activator; Chromatin regulator; Metal-binding; Nucleus; Transcription; KW Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1 209 SAGA-associated factor 11 homolog 1. FT /FTId=PRO_0000367532. FT ZN_FING 120 141 SGF11-type. SQ SEQUENCE 209 AA; 22684 MW; 110ABCF23F669012 CRC64; MSRTIVVKNP RTSGKDEDKA QIPSQDELPS GSSGAKTTNQ IISEFRALIK DPIKLDEAVN YLYETLVDDA AVGIFIETRQ LQKTGSLTAL EGTVEETNDM CDLPDCDIFG MSTAEKTAKC CCPNCERMVA AVRFAPHLQT CLGLGRSSSR AALRRLTVSS RSSSTSTGGG QANEKSTDDE DWSLDSRPGK STKNSRNKGS KKNQKNKLK //