ID LPXC_BURCJ Reviewed; 305 AA. AC B4E5Y5; DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 09-FEB-2010, entry version 14. DE RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; DE EC=3.5.1.-; DE AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase; GN Name=lpxC; OrderedLocusNames=BceJ2315_33930; ORFNames=BCAL3455; OS Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia OS cenocepacia (strain J2315)). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex. OX NCBI_TaxID=216591; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Holden M.T.G.; RT "Genomic analysis of Burkholderia cenocepacia J2315, an epidemic RT cystic fibrosis pathogen."; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the biosynthesis of lipid A, a CC phosphorylated glycolipid that anchors the lipopolysaccharide to CC the outer membrane of the cell (By similarity). CC -!- CATALYTIC ACTIVITY: UDP-3-O-(3-hydroxytetradecanoyl)-N- CC acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)- CC glucosamine + acetate. CC -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid CC IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and CC UDP-N-acetyl-alpha-D-glucosamine: step 2/6. CC -!- SIMILARITY: Belongs to the lpxC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM747720; CAR53778.1; -; Genomic_DNA. DR RefSeq; YP_002232557.1; -. DR GeneID; 6933225; -. DR GenomeReviews; AM747720_GR; BceJ2315_33930. DR KEGG; bcj:BCAL3455; -. DR HOGENOM; HBG482342; -. DR OMA; TGVGVHS; -. DR GO; GO:0008759; F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucos...; IEA:HAMAP. DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00388; LpxC; 1; -. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR004463; UDP-acyl_GlcNac_deAcase. DR InterPro; IPR011334; UDP-acyl_GlcNac_deAcase_C. DR InterPro; IPR015870; UDP-acyl_N-AcGlcN_deAcase_N. DR Gene3D; G3DSA:3.30.1700.10; UDP-acyl_N-AcGlcN_deAcase_C; 1. DR Gene3D; G3DSA:3.30.230.20; UDP-acyl_N-AcGlcN_deAcase_N; 1. DR Pfam; PF03331; LpxC; 1. DR TIGRFAMs; TIGR00325; lpxC; 1. PE 3: Inferred from homology; KW Complete proteome; Hydrolase; Lipid A biosynthesis; Lipid synthesis. FT CHAIN 1 305 UDP-3-O-[3-hydroxymyristoyl] N- FT acetylglucosamine deacetylase. FT /FTId=PRO_1000122767. SQ SEQUENCE 305 AA; 33506 MW; B50FCEB0DA411055 CRC64; MLKQRTIKSI VKTVGIGVHS GRKIELTLRP AAPGTGIVFS RVDLPTPVDI PASAMSIGDT RLASVLQKDG VRVSTVEHLM SACAGLGIDN LYVDVTAEEI PIMDGSAATF VFLIQSAGIE EQNAPKRFIK VKKPVEIRDG DKFARLDPYF GFKLKFSIDF RHPAVDKTGQ ELEVDFATTS YVREIARART FGFAHEAEML REIGLARGGS MDNAIVLDEY RILNNDGLRY DDEFVKHKML DAIGDLYVIG HPLLASYTAY KSGHGLNNAL LRELLAHEDA YEIVTFDDPQ AAPKGFAFDA QTAFA //