ID B4E160_HUMAN Unreviewed; 136 AA. AC B4E160; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 24-JUL-2024, entry version 56. DE RecName: Full=Adaptin ear-binding coat-associated protein 1 {ECO:0000256|ARBA:ARBA00040664}; DE AltName: Full=NECAP endocytosis-associated protein 1 {ECO:0000256|ARBA:ARBA00042069}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64672.1}; RN [1] {ECO:0000313|EMBL:BAG64672.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Kidney {ECO:0000313|EMBL:BAG64672.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in endocytosis. {ECO:0000256|ARBA:ARBA00002550}. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle CC membrane {ECO:0000256|ARBA:ARBA00004640}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. CC -!- SIMILARITY: Belongs to the NECAP family. CC {ECO:0000256|ARBA:ARBA00007736}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK303675; BAG64672.1; -; mRNA. DR AlphaFoldDB; B4E160; -. DR PeptideAtlas; B4E160; -. DR ProteomicsDB; 5728; -. DR GO; GO:0030125; C:clathrin vesicle coat; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0006897; P:endocytosis; IEA:InterPro. DR CDD; cd13228; PHear_NECAP; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR InterPro; IPR012466; NECAP_PHear. DR InterPro; IPR011993; PH-like_dom_sf. DR PANTHER; PTHR12847:SF15; ADAPTIN EAR-BINDING COAT-ASSOCIATED PROTEIN 1; 1. DR PANTHER; PTHR12847; ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED; 1. DR Pfam; PF07933; DUF1681; 1. DR SUPFAM; SSF50729; PH domain-like; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 7..115 FT /note="NECAP PHear" FT /evidence="ECO:0000259|Pfam:PF07933" FT REGION 117..136 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 136 AA; 15142 MW; AD96E4D30020F00C CRC64; MATELEYESV LCVKPDVSVY RIPPRASNRG YRASDWKLDQ PDWTGRLRIT SKGKTAYIKL EDKVSGELFA QAPVEQYPGI AVETVTDSSR YFVIRIQDGT GRSAFIGIGF TDRGDFSTAS SSVPNQAPQP SNWVQF //