ID B4DZB5_HUMAN Unreviewed; 229 AA. AC B4DZB5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 29-MAY-2024, entry version 61. DE RecName: Full=Serine hydroxymethyltransferase, cytosolic {ECO:0000256|ARBA:ARBA00039530}; DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256}; DE AltName: Full=Glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00032953}; DE AltName: Full=Serine methylase {ECO:0000256|ARBA:ARBA00031137}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64027.1}; RN [1] {ECO:0000313|EMBL:BAG64027.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAG64027.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; CC Evidence={ECO:0000256|ARBA:ARBA00001933}; CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. CC {ECO:0000256|ARBA:ARBA00004777}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK302834; BAG64027.1; -; mRNA. DR AlphaFoldDB; B4DZB5; -. DR SMR; B4DZB5; -. DR PeptideAtlas; B4DZB5; -. DR UniPathway; UPA00193; -. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0050897; F:cobalt ion binding; IEA:TreeGrafter. DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. DR GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:TreeGrafter. DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:TreeGrafter. DR GO; GO:0042803; F:protein homodimerization activity; IEA:TreeGrafter. DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. DR GO; GO:0070905; F:serine binding; IEA:TreeGrafter. DR GO; GO:0008270; F:zinc ion binding; IEA:TreeGrafter. DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:TreeGrafter. DR GO; GO:0046655; P:folic acid metabolic process; IEA:TreeGrafter. DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro. DR GO; GO:0006565; P:L-serine catabolic process; IEA:TreeGrafter. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR GO; GO:0051289; P:protein homotetramerization; IEA:TreeGrafter. DR GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:TreeGrafter. DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1. DR InterPro; IPR015424; PyrdxlP-dep_Trfase. DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major. DR InterPro; IPR001085; Ser_HO-MeTrfase. DR InterPro; IPR039429; SHMT-like_dom. DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1. DR PANTHER; PTHR11680:SF35; SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC; 1. DR Pfam; PF00464; SHMT; 1. DR SUPFAM; SSF53383; PLP-dependent transferases; 1. PE 2: Evidence at transcript level; KW Methyltransferase {ECO:0000313|EMBL:BAG64027.1}; KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}; KW Transferase {ECO:0000313|EMBL:BAG64027.1}. FT DOMAIN 26..202 FT /note="Serine hydroxymethyltransferase-like" FT /evidence="ECO:0000259|Pfam:PF00464" SQ SEQUENCE 229 AA; 25459 MW; 7233100E1819321B CRC64; MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA LQAYKLDPQC WGVNVQPYSG SPANFAVYTA LVEPHGRIMG LDLPDGGHLT HGFMTDKKKI SATSIFFESM PYKVNPDTGY INYDQLEENA RLFHPKLIIA GDARGGKSPC SPVAWCLLQN EDGKMFAPC //