ID B4DYU9_HUMAN Unreviewed; 514 AA. AC B4DYU9; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 22-FEB-2023, entry version 48. DE RecName: Full=Origin recognition complex subunit 2 {ECO:0000256|ARBA:ARBA00019080, ECO:0000256|RuleBase:RU368084}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63861.1}; RN [1] {ECO:0000313|EMBL:BAG63861.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAG63861.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BAH14804.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAH14804.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds CC origins of replication. DNA-binding is ATP-dependent. ORC is required CC to assemble the pre-replication complex necessary to initiate DNA CC replication. {ECO:0000256|RuleBase:RU368084}. CC -!- SUBUNIT: Component of the origin recognition complex (ORC). CC {ECO:0000256|RuleBase:RU368084}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|RuleBase:RU368084}. CC -!- SIMILARITY: Belongs to the ORC2 family. {ECO:0000256|ARBA:ARBA00007421, CC ECO:0000256|RuleBase:RU368084}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK302614; BAG63861.1; -; mRNA. DR EMBL; AK316433; BAH14804.1; -; mRNA. DR AlphaFoldDB; B4DYU9; -. DR PeptideAtlas; B4DYU9; -. DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:UniProtKB-UniRule. DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule. DR InterPro; IPR007220; ORC2. DR PANTHER; PTHR14052; ORIGIN RECOGNITION COMPLEX SUBUNIT 2; 1. DR PANTHER; PTHR14052:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 2; 1. DR Pfam; PF04084; ORC2; 1. PE 2: Evidence at transcript level; KW DNA replication {ECO:0000256|ARBA:ARBA00022705, KW ECO:0000256|RuleBase:RU368084}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368084}. FT REGION 81..199 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 81..97 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 115..146 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 514 AA; 58667 MW; 9B951D3CB43339F1 CRC64; MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV LRSLTPNARG IFRLLIKYQL DNQDNPSYIG IQYL //