ID   B4DVE5_HUMAN            Unreviewed;       362 AA.
AC   B4DVE5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   02-OCT-2024, entry version 73.
DE   RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62657.1};
RN   [1] {ECO:0000313|EMBL:BAG62657.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAG62657.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms the heterodimeric complex core-binding factor (CBF)
CC       with CBFB. RUNX members modulate the transcription of their target
CC       genes through recognizing the core consensus binding sequence 5'-
CC       TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory
CC       regions via their runt domain, while CBFB is a non-DNA-binding
CC       regulatory subunit that allosterically enhances the sequence-specific
CC       DNA-binding capacity of RUNX. {ECO:0000256|PIRNR:PIRNR009374}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR009374}.
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DR   EMBL; AK301044; BAG62657.1; -; mRNA.
DR   AlphaFoldDB; B4DVE5; -.
DR   PeptideAtlas; B4DVE5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.40.720; -; 1.
DR   InterPro; IPR000040; AML1_Runt.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR   InterPro; IPR013524; Runt_dom.
DR   InterPro; IPR013711; RunxI_C_dom.
DR   InterPro; IPR016554; TF_Runt-rel_RUNX.
DR   PANTHER; PTHR11950; RUNT RELATED; 1.
DR   PANTHER; PTHR11950:SF43; RUNT-RELATED TRANSCRIPTION FACTOR 3; 1.
DR   Pfam; PF00853; Runt; 1.
DR   Pfam; PF08504; RunxI; 1.
DR   PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 2.
DR   PRINTS; PR00967; ONCOGENEAML1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS51062; RUNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR009374};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transcription {ECO:0000256|PIRNR:PIRNR009374};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}.
FT   DOMAIN          54..182
FT                   /note="Runt"
FT                   /evidence="ECO:0000259|PROSITE:PS51062"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         116
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT   BINDING         120
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT   BINDING         143
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT   BINDING         174
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
SQ   SEQUENCE   362 AA;  38366 MW;  67C65E13E604F687 CRC64;
     MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA
     DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE
     LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP
     RRTSELNPFS DPRQFDRSFP TLPTLTESRF PDPRMHYPGA MSAAFPYSAT PSGTSISSLS
     VAGMPATSRF HHTYLPPPYP GAPQNQNGPF QANPSPYHLY YGTSSGSYQF SMVAGSSSGG
     DRSPTRMLAS CTSSAASVAA GNLMNPSLGG QSDGVEADGS HSNSPTALST PGRMDEAVWR
     PY
//