ID B4DVE5_HUMAN Unreviewed; 362 AA. AC B4DVE5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 08-NOV-2023, entry version 68. DE RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62657.1}; RN [1] {ECO:0000313|EMBL:BAG62657.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spleen {ECO:0000313|EMBL:BAG62657.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) CC with CBFB. RUNX members modulate the transcription of their target CC genes through recognizing the core consensus binding sequence 5'- CC TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory CC regions via their runt domain, while CBFB is a non-DNA-binding CC regulatory subunit that allosterically enhances the sequence-specific CC DNA-binding capacity of RUNX. {ECO:0000256|PIRNR:PIRNR009374}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PIRNR:PIRNR009374}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK301044; BAG62657.1; -; mRNA. DR AlphaFoldDB; B4DVE5; -. DR MaxQB; B4DVE5; -. DR PeptideAtlas; B4DVE5; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-UniRule. DR Gene3D; 2.60.40.720; -; 1. DR InterPro; IPR000040; AML1_Runt. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf. DR InterPro; IPR013524; Runt_dom. DR InterPro; IPR013711; RunxI_C_dom. DR InterPro; IPR016554; TF_Runt-rel_RUNX. DR PANTHER; PTHR11950; RUNT RELATED; 1. DR PANTHER; PTHR11950:SF43; RUNT-RELATED TRANSCRIPTION FACTOR 3; 1. DR Pfam; PF00853; Runt; 1. DR Pfam; PF08504; RunxI; 1. DR PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 2. DR PRINTS; PR00967; ONCOGENEAML1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS51062; RUNT; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|PIRNR:PIRNR009374}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, KW ECO:0000256|PIRNR:PIRNR009374}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|PIRNR:PIRNR009374}. FT DOMAIN 54..182 FT /note="Runt" FT /evidence="ECO:0000259|PROSITE:PS51062" FT REGION 1..48 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 178..213 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 322..362 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 336..350 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 116 FT /ligand="chloride" FT /ligand_id="ChEBI:CHEBI:17996" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1" FT BINDING 120 FT /ligand="chloride" FT /ligand_id="ChEBI:CHEBI:17996" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1" FT BINDING 143 FT /ligand="chloride" FT /ligand_id="ChEBI:CHEBI:17996" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1" FT BINDING 174 FT /ligand="chloride" FT /ligand_id="ChEBI:CHEBI:17996" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1" SQ SEQUENCE 362 AA; 38366 MW; 67C65E13E604F687 CRC64; MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP RRTSELNPFS DPRQFDRSFP TLPTLTESRF PDPRMHYPGA MSAAFPYSAT PSGTSISSLS VAGMPATSRF HHTYLPPPYP GAPQNQNGPF QANPSPYHLY YGTSSGSYQF SMVAGSSSGG DRSPTRMLAS CTSSAASVAA GNLMNPSLGG QSDGVEADGS HSNSPTALST PGRMDEAVWR PY //