ID B4DVE5_HUMAN Unreviewed; 362 AA. AC B4DVE5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 31-JUL-2019, entry version 56. DE RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62657.1}; RN [1] {ECO:0000313|EMBL:BAG62657.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spleen {ECO:0000313|EMBL:BAG62657.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms the heterodimeric complex core-binding factor CC (CBF) with CBFB. RUNX members modulate the transcription of their CC target genes through recognizing the core consensus binding CC sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their CC regulatory regions via their runt domain, while CBFB is a non-DNA- CC binding regulatory subunit that allosterically enhances the CC sequence-specific DNA-binding capacity of RUNX. CC {ECO:0000256|PIRNR:PIRNR009374}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009374}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK301044; BAG62657.1; -; mRNA. DR MaxQB; B4DVE5; -. DR PeptideAtlas; B4DVE5; -. DR PRIDE; B4DVE5; -. DR HOGENOM; HOG000045616; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule. DR Gene3D; 2.60.40.720; -; 1. DR InterPro; IPR000040; AML1_Runt. DR InterPro; IPR008967; p53-like_TF_DNA-bd. DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf. DR InterPro; IPR013524; Runt_dom. DR InterPro; IPR013711; RunxI_C_dom. DR InterPro; IPR016554; TF_Runt-rel_RUNX. DR PANTHER; PTHR11950; PTHR11950; 2. DR Pfam; PF00853; Runt; 1. DR Pfam; PF08504; RunxI; 1. DR PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 2. DR PRINTS; PR00967; ONCOGENEAML1. DR SUPFAM; SSF49417; SSF49417; 1. DR PROSITE; PS51062; RUNT; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|PIRNR:PIRNR009374}; KW Transcription {ECO:0000256|PIRNR:PIRNR009374}; KW Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}. FT DOMAIN 54 182 Runt. {ECO:0000259|PROSITE:PS51062}. FT REGION 1 48 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 178 213 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 322 362 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 336 350 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT BINDING 116 116 Chloride 1. {ECO:0000256|PIRSR: FT PIRSR009374-1}. FT BINDING 120 120 Chloride 1; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR009374-1}. FT BINDING 143 143 Chloride 2. {ECO:0000256|PIRSR: FT PIRSR009374-1}. FT BINDING 174 174 Chloride 2; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR009374-1}. SQ SEQUENCE 362 AA; 38366 MW; 67C65E13E604F687 CRC64; MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP RRTSELNPFS DPRQFDRSFP TLPTLTESRF PDPRMHYPGA MSAAFPYSAT PSGTSISSLS VAGMPATSRF HHTYLPPPYP GAPQNQNGPF QANPSPYHLY YGTSSGSYQF SMVAGSSSGG DRSPTRMLAS CTSSAASVAA GNLMNPSLGG QSDGVEADGS HSNSPTALST PGRMDEAVWR PY //