ID   B4DVE5_HUMAN            Unreviewed;       362 AA.
AC   B4DVE5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   20-JUN-2018, entry version 51.
DE   RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62657.1};
RN   [1] {ECO:0000313|EMBL:BAG62657.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAG62657.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms the heterodimeric complex core-binding factor
CC       (CBF) with CBFB. RUNX members modulate the transcription of their
CC       target genes through recognizing the core consensus binding
CC       sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their
CC       regulatory regions via their runt domain, while CBFB is a non-DNA-
CC       binding regulatory subunit that allosterically enhances the
CC       sequence-specific DNA-binding capacity of RUNX.
CC       {ECO:0000256|PIRNR:PIRNR009374}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009374}.
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DR   EMBL; AK301044; BAG62657.1; -; mRNA.
DR   UniGene; Hs.170019; -.
DR   MaxQB; B4DVE5; -.
DR   PeptideAtlas; B4DVE5; -.
DR   PRIDE; B4DVE5; -.
DR   HOGENOM; HOG000045616; -.
DR   HOVERGEN; HBG060268; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.720; -; 1.
DR   InterPro; IPR000040; AML1_Runt.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR   InterPro; IPR013524; Runt_dom.
DR   InterPro; IPR013711; RunxI_C_dom.
DR   InterPro; IPR016554; TF_Runt-rel_RUNX.
DR   PANTHER; PTHR11950; PTHR11950; 2.
DR   Pfam; PF00853; Runt; 1.
DR   Pfam; PF08504; RunxI; 1.
DR   PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 2.
DR   PRINTS; PR00967; ONCOGENEAML1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS51062; RUNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR009374};
KW   Transcription {ECO:0000256|PIRNR:PIRNR009374};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}.
FT   DOMAIN       54    182       Runt. {ECO:0000259|PROSITE:PS51062}.
FT   BINDING     116    116       Chloride 1. {ECO:0000256|PIRSR:
FT                                PIRSR009374-1}.
FT   BINDING     120    120       Chloride 1; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR009374-1}.
FT   BINDING     143    143       Chloride 2. {ECO:0000256|PIRSR:
FT                                PIRSR009374-1}.
FT   BINDING     174    174       Chloride 2; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR009374-1}.
SQ   SEQUENCE   362 AA;  38366 MW;  67C65E13E604F687 CRC64;
     MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA
     DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE
     LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP
     RRTSELNPFS DPRQFDRSFP TLPTLTESRF PDPRMHYPGA MSAAFPYSAT PSGTSISSLS
     VAGMPATSRF HHTYLPPPYP GAPQNQNGPF QANPSPYHLY YGTSSGSYQF SMVAGSSSGG
     DRSPTRMLAS CTSSAASVAA GNLMNPSLGG QSDGVEADGS HSNSPTALST PGRMDEAVWR
     PY
//