ID B4DM00_HUMAN Unreviewed; 528 AA. AC B4DM00; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 11-NOV-2015, entry version 30. DE SubName: Full=cDNA FLJ54367, highly similar to Amyloid beta A4 protein (APP) (ABPP)(Alzheimer disease amyloid protein homolog) {ECO:0000313|EMBL:BAG59712.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59712.1}; RN [1] {ECO:0000313|EMBL:BAG59712.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAG59712.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK297229; BAG59712.1; -; mRNA. DR UniGene; Hs.434980; -. DR STRING; 9606.ENSP00000284981; -. DR PaxDb; B4DM00; -. DR PRIDE; B4DM00; -. DR eggNOG; KOG3540; Eukaryota. DR eggNOG; ENOG410ZW2A; LUCA. DR HOVERGEN; HBG000051; -. DR NextBio; 35473181; -. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0008201; F:heparin binding; IEA:InterPro. DR GO; GO:0007399; P:nervous system development; IEA:InterPro. DR Gene3D; 3.90.570.10; -; 1. DR Gene3D; 4.10.230.10; -; 1. DR InterPro; IPR008155; Amyloid_glyco. DR InterPro; IPR013803; Amyloid_glyco_Abeta. DR InterPro; IPR024329; Amyloid_glyco_E2_domain. DR InterPro; IPR015849; Amyloid_glyco_heparin-bd. DR InterPro; IPR019745; Amyloid_glyco_intracell_CS. DR InterPro; IPR028866; APP. DR InterPro; IPR019543; APP_amyloid_C. DR PANTHER; PTHR23103:SF7; PTHR23103:SF7; 1. DR Pfam; PF10515; APP_amyloid; 1. DR Pfam; PF12925; APP_E2; 1. DR Pfam; PF02177; APP_N; 1. DR Pfam; PF03494; Beta-APP; 1. DR PRINTS; PR00203; AMYLOIDA4. DR PRINTS; PR00204; BETAAMYLOID. DR SUPFAM; SSF109843; SSF109843; 1. DR SUPFAM; SSF56491; SSF56491; 1. DR PROSITE; PS00320; A4_INTRA; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 528 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002803142. FT TRANSMEM 459 481 Helical. {ECO:0000256|SAM:Phobius}. FT COILED 157 177 {ECO:0000256|SAM:Coils}. FT COILED 183 217 {ECO:0000256|SAM:Coils}. FT COILED 313 333 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 528 AA; 60074 MW; BDBBEAA72994D7D6 CRC64; MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DAVDKYLETP GDENEHAHFQ KAKERLEAKH RERMSQVMRE WEEAERQAKN LPKADKKAVI QHFQEKVESL EQEAANERQQ LVETHMARVE AMLNDRRRLA LENYITALQA VPPRPRHVFN MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN QSLSLLYNVP AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA LMPSLTETKT TVELLPVNGE FSLDDLQPWH SFGADSVPAN TENEVEPVDA RPAADRGLTT RPGSGLTNIK TEEISEVKMD AEFRHDSGYE VHHQKLVFFA EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV TPEERHLSKM QQNGYENPTY KFFEQMQN //