ID B4DL33_HUMAN Unreviewed; 401 AA. AC B4DL33; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 87. DE RecName: Full=Frizzled-6 {ECO:0000256|ARBA:ARBA00018155}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59395.1}; RN [1] {ECO:0000313|EMBL:BAG59395.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Tongue {ECO:0000313|EMBL:BAG59395.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651}. Cell surface CC {ECO:0000256|ARBA:ARBA00004241}. Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004439}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. CC {ECO:0000256|ARBA:ARBA00008077}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK296824; BAG59395.1; -; mRNA. DR RefSeq; NP_001304725.1; NM_001317796.1. DR AlphaFoldDB; B4DL33; -. DR PeptideAtlas; B4DL33; -. DR DNASU; 8323; -. DR GeneID; 8323; -. DR CTD; 8323; -. DR OrthoDB; 5483535at2759; -. DR BioGRID-ORCS; 8323; 9 hits in 1157 CRISPR screens. DR GenomeRNAi; 8323; -. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR000539; Frizzled/Smoothened_7TM. DR InterPro; IPR017981; GPCR_2-like_7TM. DR PANTHER; PTHR11309; FRIZZLED; 1. DR PANTHER; PTHR11309:SF75; FRIZZLED-6; 1. DR Pfam; PF01534; Frizzled; 1. DR PRINTS; PR00489; FRIZZLED. DR SMART; SM01330; Frizzled; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}. FT TRANSMEM 20..40 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 64..88 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 108..133 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 168..189 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..197 FT /note="G-protein coupled receptors family 2 profile 2" FT /evidence="ECO:0000259|PROSITE:PS50261" FT REGION 283..401 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 353..381 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 401 AA; 44287 MW; B5CF3EEAE9E1706B CRC64; MTRVLPRWKW SCEAIEQKAV WFHAVAWGTP GFLTVMLLAL NKVEGDNISG VCFVGLYDLD ASRYFVLLPL CLCVFVGLSL LLAGIISLNH VRQVIQHDGR NQEKLKKFMI RIGVFSGLYL VPLVTLLGCY VYEQVNRITW EITWVSDHCR QYHIPCPYQA KAKARPELAL FMIKYLMTLI VGISAVFWVG SKKTCTEWAG FFKRNRKRDP ISESRRVLQE SCEFFLKHNS KVKHKKKHYK PSSHKLKVIS KSMGTSTGAT ANHGTSAVAI TSHDYLGQET LTEIQTSPET SMREVKADGA STPRLREQDC GEPASPAASI SRLSGEQVDG KGQAGSVSES ARSEGRISPK SDITDTGLAQ SNNLQVPSSS EPSSLKGSTS LLVHPVSGVR KEQGGGCHSD T //