ID B4DL33_HUMAN Unreviewed; 401 AA. AC B4DL33; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 25-OCT-2017, entry version 60. DE SubName: Full=cDNA FLJ57315, highly similar to Frizzled-6 {ECO:0000313|EMBL:BAG59395.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59395.1}; RN [1] {ECO:0000313|EMBL:BAG59395.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Tongue {ECO:0000313|EMBL:BAG59395.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo CC family. {ECO:0000256|SAAS:SAAS00593381}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK296824; BAG59395.1; -; mRNA. DR RefSeq; NP_001304725.1; NM_001317796.1. DR UniGene; Hs.591863; -. DR UniGene; Hs.676099; -. DR PaxDb; B4DL33; -. DR PeptideAtlas; B4DL33; -. DR PRIDE; B4DL33; -. DR GeneID; 8323; -. DR CTD; 8323; -. DR eggNOG; KOG3577; Eukaryota. DR eggNOG; ENOG410XRC8; LUCA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042813; F:Wnt-activated receptor activity; IEA:InterPro. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR000539; Frizzled/Smoothened_TM. DR InterPro; IPR026543; FZD6. DR InterPro; IPR017981; GPCR_2-like. DR PANTHER; PTHR11309; PTHR11309; 1. DR PANTHER; PTHR11309:SF75; PTHR11309:SF75; 1. DR Pfam; PF01534; Frizzled; 1. DR PRINTS; PR00489; FRIZZLED. DR SMART; SM01330; Frizzled; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|SAAS:SAAS00521519, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00521527}; KW Transmembrane {ECO:0000256|SAAS:SAAS00521521, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00521525, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 20 40 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 64 88 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 133 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 168 189 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 197 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 401 AA; 44287 MW; B5CF3EEAE9E1706B CRC64; MTRVLPRWKW SCEAIEQKAV WFHAVAWGTP GFLTVMLLAL NKVEGDNISG VCFVGLYDLD ASRYFVLLPL CLCVFVGLSL LLAGIISLNH VRQVIQHDGR NQEKLKKFMI RIGVFSGLYL VPLVTLLGCY VYEQVNRITW EITWVSDHCR QYHIPCPYQA KAKARPELAL FMIKYLMTLI VGISAVFWVG SKKTCTEWAG FFKRNRKRDP ISESRRVLQE SCEFFLKHNS KVKHKKKHYK PSSHKLKVIS KSMGTSTGAT ANHGTSAVAI TSHDYLGQET LTEIQTSPET SMREVKADGA STPRLREQDC GEPASPAASI SRLSGEQVDG KGQAGSVSES ARSEGRISPK SDITDTGLAQ SNNLQVPSSS EPSSLKGSTS LLVHPVSGVR KEQGGGCHSD T //