ID B4DI18_HUMAN Unreviewed; 188 AA. AC B4DI18; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 22-FEB-2023, entry version 68. DE RecName: Full=Mitochondrial import inner membrane translocase subunit TIM23 {ECO:0000256|RuleBase:RU364003}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG58330.1}; RN [1] {ECO:0000313|EMBL:BAG58330.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Corpus callosum {ECO:0000313|EMBL:BAG58330.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BAG65627.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAG65627.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that CC mediates the translocation of transit peptide-containing proteins CC across the mitochondrial inner membrane. CC {ECO:0000256|RuleBase:RU364003}. CC -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23, CC TIMM17 (TIMM17A or TIMM17B) and TIMM50. CC {ECO:0000256|RuleBase:RU364003}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU364003}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU364003}. CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. CC {ECO:0000256|ARBA:ARBA00008444, ECO:0000256|RuleBase:RU364003}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK295370; BAG58330.1; -; mRNA. DR EMBL; AK316549; BAG65627.1; -; mRNA. DR AlphaFoldDB; B4DI18; -. DR MaxQB; B4DI18; -. DR PeptideAtlas; B4DI18; -. DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:InterPro. DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro. DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro. DR InterPro; IPR005681; Tim23. DR InterPro; IPR045238; Tim23-like. DR PANTHER; PTHR15371:SF34; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23B; 1. DR PANTHER; PTHR15371; TIM23; 1. DR Pfam; PF02466; Tim17; 1. DR TIGRFAMs; TIGR00983; 3a0801s02tim23; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364003}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU364003}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU364003}; KW Protein transport {ECO:0000256|RuleBase:RU364003}; KW Translocation {ECO:0000256|ARBA:ARBA00023010, KW ECO:0000256|RuleBase:RU364003}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU364003}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU364003}; Transport {ECO:0000256|RuleBase:RU364003}. FT TRANSMEM 75..96 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364003" FT TRANSMEM 126..145 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364003" SQ SEQUENCE 188 AA; 19653 MW; D0E46DBB03A32C08 CRC64; MEGGGGSGDK TTGVLAGFFG AGEAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF ILPTGANKTW GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PGNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TVSEMALDSP FCVLLSGS //