ID B4DFY0_HUMAN Unreviewed; 534 AA. AC B4DFY0; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 07-OCT-2020, entry version 60. DE SubName: Full=cDNA FLJ53313, highly similar to Alpha-actinin-1 {ECO:0000313|EMBL:BAG57591.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57591.1}; RN [1] {ECO:0000313|EMBL:BAG57591.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Amygdala {ECO:0000313|EMBL:BAG57591.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK294317; BAG57591.1; -; mRNA. DR PeptideAtlas; B4DFY0; -. DR GO; GO:0051015; F:actin filament binding; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0051764; P:actin crosslink formation; IEA:InterPro. DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro. DR CDD; cd00051; EFh; 1. DR InterPro; IPR026921; Alpha-actinin_1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR014837; EF-hand_Ca_insen. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR018159; Spectrin/alpha-actinin. DR InterPro; IPR002017; Spectrin_repeat. DR PANTHER; PTHR11915:SF434; PTHR11915:SF434; 1. DR Pfam; PF08726; EFhand_Ca_insen; 1. DR Pfam; PF00435; Spectrin; 3. DR SMART; SM00054; EFh; 2. DR SMART; SM00150; SPEC; 3. DR SUPFAM; SSF47473; SSF47473; 1. DR PROSITE; PS50222; EF_HAND_2; 2. PE 2: Evidence at transcript level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Coiled coil {ECO:0000256|SAM:Coils}. FT DOMAIN 393..428 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 429..464 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT COILED 77..111 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 534 AA; 61575 MW; B10994C30BF90D57 CRC64; MPSEGRMVSD INNAWGCLGQ VEKGYEEWLL NEIRRLERLD HLAEKFRQKA SIHEAWTDGK EAMLRQKDYE TATLSEIKAL LKKHEAFESD LAAHQDRVEQ IAAIAQELNE LDYYDSPSVN ARCQKICDQW DNLGALTQKR REALERTEKL LETIDQLYLE YAKRAAPFNN WMEGAMEDLQ DTFIVHTIEE IQGLTTAHEQ FKATLPDADK ERLAILGIHN EVSKIVQTYH VNMAGTNPYT TITPQEINGK WDHVRQLVPR RDQALTEEHA RQQHNERLRK QFGAQANVIG PWIQTKMEEI GRISIEMHGT LEDQLSHLRQ YEKSIVNYKP KIDQLEGDHQ LIQEALIFDN KHTNYTMEHI RVGWEQLLTT IARTINEVEN QILTRDAKGI SQEQMNEFRA SFNHFDRKKT GMMDTDDFRA CLISMGYNMG EAEFARIMSI VDPNRLGVVT FQAFIDFMSR ETADTDTADQ VMASFKILAG DKNYITMDEL RRELPPDQAE YCIARMAPYT GPDSVPGALD YMSFSTALYG ESDL //