ID B4DER0_HUMAN Unreviewed; 548 AA. AC B4DER0; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 29-MAY-2024, entry version 62. DE SubName: Full=cDNA FLJ56938, highly similar to Semaphorin-4D {ECO:0000313|EMBL:BAG57171.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57171.1}; RN [1] {ECO:0000313|EMBL:BAG57171.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Cerebellum {ECO:0000313|EMBL:BAG57171.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK293749; BAG57171.1; -; mRNA. DR AlphaFoldDB; B4DER0; -. DR PeptideAtlas; B4DER0; -. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0045499; F:chemorepellent activity; IEA:TreeGrafter. DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro. DR GO; GO:0007411; P:axon guidance; IEA:TreeGrafter. DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:TreeGrafter. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:TreeGrafter. DR GO; GO:0001755; P:neural crest cell migration; IEA:TreeGrafter. DR GO; GO:0043931; P:ossification involved in bone maturation; IEA:TreeGrafter. DR GO; GO:0030335; P:positive regulation of cell migration; IEA:TreeGrafter. DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:TreeGrafter. DR CDD; cd11259; Sema_4D; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR036352; Semap_dom_sf. DR InterPro; IPR027231; Semaphorin. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR11036; SEMAPHORIN; 1. DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1. DR Pfam; PF01403; Sema; 1. DR SMART; SM00630; Sema; 1. DR SUPFAM; SSF101912; Sema domain; 1. DR PROSITE; PS51004; SEMA; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..548 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002800764" FT DOMAIN 19..499 FT /note="Sema" FT /evidence="ECO:0000259|PROSITE:PS51004" SQ SEQUENCE 548 AA; 61669 MW; DBEBEC6B06CD6BAB CRC64; MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE DGKGRCPFDP AHSYTSVMVD GELYLGTSYN FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR SPGLKVPVFY ALFTPQLNNV GLSAVCTYNL STAEEVFSHG KYMQSTTVEQ SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKVLQTFALS GRRMGELWRP VSLCRPMHCP MAGPMHSAGC RTPSGKALSI AALSSPQQGT RLRRCRLL //