ID B3VAR5_HBV Unreviewed; 212 AA. AC B3VAR5; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 20-DEC-2017, entry version 36. DE RecName: Full=Capsid protein {ECO:0000256|HAMAP-Rule:MF_04076}; DE AltName: Full=Core antigen {ECO:0000256|HAMAP-Rule:MF_04076}; DE AltName: Full=Core protein {ECO:0000256|HAMAP-Rule:MF_04076}; DE AltName: Full=HBcAg {ECO:0000256|HAMAP-Rule:MF_04076}; DE AltName: Full=p21.5 {ECO:0000256|HAMAP-Rule:MF_04076}; GN Name=C {ECO:0000256|HAMAP-Rule:MF_04076, GN ECO:0000256|RuleBase:RU361253}; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACE76045.1}; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ACE76045.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=IR-RCGLD-7064 {ECO:0000313|EMBL:ACE76045.1}; RA Mohebbi S.R., Amini-Bavil-Olyaee S., Zali N., Derakhshan F., RA Chiani M., Rostami Nejad M., Sabahi F., Zali M.R.; RT "Molecular Epidemiology of Hepatitis B Virus in Iran."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Encapsidates hepatitis delta genome. {ECO:0000256|HAMAP- CC Rule:MF_04076}. CC -!- FUNCTION: May regulate immune response to the intracellular capsid CC in acting as a T-cell tolerogen, by having an immunoregulatory CC effect which prevents destruction of infected cells by cytotoxic CC T-cells. {ECO:0000256|RuleBase:RU361253}. CC -!- FUNCTION: Self assembles to form an icosahedral capsid. Most CC capsid appear to be large particles with a icosahedral symmetry of CC T=4 and consist of 240 copies of capsid protein, though a fraction CC forms smaller T=3 particles consisting of 180 capsid proteins. CC Entering capsid are transported along microtubules to the nucleus. CC Phosphorylation of the capsid is thought to induce exposure of CC nuclear localization signal in the C-terminal portion of the CC capsid protein that allows binding to the nuclear pore complex via CC the importin (karyopherin-) alpha and beta. Capsids are imported CC in intact form through the nuclear pore into the nuclear basket, CC where it probably binds NUP153. Only capsids that contain the CC mature viral genome can release the viral DNA and capsid protein CC into the nucleoplasm. Immature capsids get stucked in the basket. CC Capsids encapsulate the pre-genomic RNA and the P protein. Pre- CC genomic RNA is reverse transcribed into DNA while the capsid is CC still in the cytoplasm. The capsid can then either be directed to CC the nucleus, providing more genome for transcription, or bud CC through the endoplasmic reticulum to provide new virions. CC {ECO:0000256|HAMAP-Rule:MF_04076}. CC -!- SUBUNIT: Homodimerizes, then multimerizes. Interacts with cytosol CC exposed regions of viral L glycoprotein present in the reticulum- CC to-Golgi compartment. Interacts with human FLNB. Phosphorylated CC form interacts with host importin alpha; this interaction depends CC on the exposure of the NLS, which itself depends upon genome CC maturation and/or phosphorylation of the capsid protein. Interacts CC with host NUP153. {ECO:0000256|HAMAP-Rule:MF_04076}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}. CC Virion {ECO:0000256|HAMAP-Rule:MF_04076}. Host cytoplasm CC {ECO:0000256|HAMAP-Rule:MF_04076}. CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}. CC -!- PTM: Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase CC C or GAPDH. Phosphorylation is critical for pregenomic RNA CC packaging. Protein kinase C phosphorylation is stimulated by HBx CC protein and may play a role in transport of the viral genome to CC the nucleus at the late step during viral replication cycle. CC {ECO:0000256|HAMAP-Rule:MF_04076}. CC -!- SIMILARITY: Belongs to the orthohepadnavirus core antigen family. CC {ECO:0000256|HAMAP-Rule:MF_04076}. CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen CC family. {ECO:0000256|RuleBase:RU361253}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU726883; ACE76045.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:InterPro. DR Gene3D; 1.10.4090.10; -; 1. DR HAMAP; MF_04076; HBV_HBEAG; 1. DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N. DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV. DR InterPro; IPR002006; Viral_capsid_core_Hepatitis. DR Pfam; PF08290; Hep_core_N; 1. DR Pfam; PF00906; Hepatitis_core; 2. DR ProDom; PD000874; Vir_capsid_Znf-put_N_Hepatitis; 1. DR SUPFAM; SSF47852; SSF47852; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|HAMAP-Rule:MF_04076}; KW Cytoplasmic inwards viral transport {ECO:0000256|HAMAP-Rule:MF_04076}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_04076}; KW Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04076}; KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04076, KW ECO:0000256|RuleBase:RU361253}; KW Microtubular inwards viral transport {ECO:0000256|HAMAP- KW Rule:MF_04076}; Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04076}; KW Repeat {ECO:0000256|HAMAP-Rule:MF_04076, KW ECO:0000256|SAAS:SAAS00779256}; KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_04076}; KW T=4 icosahedral capsid protein {ECO:0000256|HAMAP-Rule:MF_04076}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}; KW Viral penetration into host nucleus {ECO:0000256|HAMAP-Rule:MF_04076}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04076}; KW Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04076}. FT DOMAIN 1 27 Hep_core_N. {ECO:0000259|Pfam:PF08290}. FT DOMAIN 31 102 Hepatitis_core. {ECO:0000259|Pfam: FT PF00906}. FT DOMAIN 116 212 Hepatitis_core. {ECO:0000259|Pfam: FT PF00906}. FT REGION 206 212 RNA binding. {ECO:0000256|HAMAP-Rule: FT MF_04076}. FT MOTIF 187 204 Bipartite nuclear localization signal. FT {ECO:0000256|HAMAP-Rule:MF_04076}. FT MOD_RES 184 184 Phosphoserine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04076}. FT MOD_RES 191 191 Phosphoserine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04076}. FT MOD_RES 199 199 Phosphoserine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04076}. SQ SEQUENCE 212 AA; 24338 MW; AFAC42A2B26A7FE6 CRC64; MQLFHLCLII SCSCPTIQAS KLCLGWLWGM DIDAYKEFGA TVELLSFLPS DFFPSVRDLL DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGGNLEDPIS RDLVVSYVNT NMGLKFRQLL WFHISCLTFG RETVIEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC //