ID B3VAR5_HBV Unreviewed; 212 AA. AC B3VAR5; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 30-AUG-2017, entry version 34. DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253}; GN Name=C {ECO:0000256|RuleBase:RU361253}; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACE76045.1}; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ACE76045.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=IR-RCGLD-7064 {ECO:0000313|EMBL:ACE76045.1}; RA Mohebbi S.R., Amini-Bavil-Olyaee S., Zali N., Derakhshan F., RA Chiani M., Rostami Nejad M., Sabahi F., Zali M.R.; RT "Molecular Epidemiology of Hepatitis B Virus in Iran."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May regulate immune response to the intracellular capsid CC in acting as a T-cell tolerogen, by having an immunoregulatory CC effect which prevents destruction of infected cells by cytotoxic CC T-cells. {ECO:0000256|RuleBase:RU361253}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}. CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}. CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}. CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen CC family. {ECO:0000256|RuleBase:RU361253}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU726883; ACE76045.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:InterPro. DR Gene3D; 1.10.4090.10; -; 1. DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N. DR InterPro; IPR002006; Viral_capsid_core_Hepatitis. DR Pfam; PF08290; Hep_core_N; 1. DR Pfam; PF00906; Hepatitis_core; 2. DR ProDom; PD000874; Vir_capsid_Znf-put_N_Hepatitis; 1. DR SUPFAM; SSF47852; SSF47852; 1. PE 3: Inferred from homology; KW Host-virus interaction {ECO:0000256|RuleBase:RU361253}; KW Repeat {ECO:0000256|SAAS:SAAS00779256}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}. FT DOMAIN 1 27 Hep_core_N. {ECO:0000259|Pfam:PF08290}. FT DOMAIN 31 102 Hepatitis_core. {ECO:0000259|Pfam: FT PF00906}. FT DOMAIN 116 212 Hepatitis_core. {ECO:0000259|Pfam: FT PF00906}. SQ SEQUENCE 212 AA; 24338 MW; AFAC42A2B26A7FE6 CRC64; MQLFHLCLII SCSCPTIQAS KLCLGWLWGM DIDAYKEFGA TVELLSFLPS DFFPSVRDLL DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGGNLEDPIS RDLVVSYVNT NMGLKFRQLL WFHISCLTFG RETVIEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC //