ID   B3VAR5_HBV              Unreviewed;       212 AA.
AC   B3VAR5;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   16-MAR-2016, entry version 24.
DE   RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
GN   Name=C {ECO:0000256|RuleBase:RU361253};
OS   Hepatitis B virus (HBV).
OC   Viruses; Retro-transcribing viruses; Hepadnaviridae;
OC   Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:ACE76045.1};
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACE76045.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IR-RCGLD-7064 {ECO:0000313|EMBL:ACE76045.1};
RA   Mohebbi S.R., Amini-Bavil-Olyaee S., Zali N., Derakhshan F.,
RA   Chiani M., Rostami Nejad M., Sabahi F., Zali M.R.;
RT   "Molecular Epidemiology of Hepatitis B Virus in Iran.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid
CC       in acting as a T-cell tolerogen, by having an immunoregulatory
CC       effect which prevents destruction of infected cells by cytotoxic
CC       T-cells. {ECO:0000256|RuleBase:RU361253}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen
CC       family. {ECO:0000256|RuleBase:RU361253}.
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DR   EMBL; EU726883; ACE76045.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Viral_capsid_core_Hepatitis.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 2.
DR   ProDom; PD000874; Vir_capsid_Znf-put_N_Hepatitis; 1.
DR   SUPFAM; SSF47852; SSF47852; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|RuleBase:RU361253,
KW   ECO:0000256|SAAS:SAAS00472214};
KW   Repeat {ECO:0000256|SAAS:SAAS00301190};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT   DOMAIN        1     27       Hep_core_N. {ECO:0000259|Pfam:PF08290}.
FT   DOMAIN       31    102       Hepatitis_core. {ECO:0000259|Pfam:
FT                                PF00906}.
FT   DOMAIN      116    212       Hepatitis_core. {ECO:0000259|Pfam:
FT                                PF00906}.
SQ   SEQUENCE   212 AA;  24338 MW;  AFAC42A2B26A7FE6 CRC64;
     MQLFHLCLII SCSCPTIQAS KLCLGWLWGM DIDAYKEFGA TVELLSFLPS DFFPSVRDLL
     DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGGNLEDPIS RDLVVSYVNT
     NMGLKFRQLL WFHISCLTFG RETVIEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
     RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC
//