ID EI3F1_DROER Reviewed; 280 AA. AC B3P239; DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 1. DT 22-NOV-2017, entry version 53. DE RecName: Full=Eukaryotic translation initiation factor 3 subunit F-1 {ECO:0000255|HAMAP-Rule:MF_03005}; DE Short=eIF3f-1 {ECO:0000255|HAMAP-Rule:MF_03005}; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-1 {ECO:0000255|HAMAP-Rule:MF_03005}; GN Name=eIF3f1 {ECO:0000255|HAMAP-Rule:MF_03005}; GN Synonyms=eIF3-S5-1 {ECO:0000255|HAMAP-Rule:MF_03005}; GN ORFNames=GG11433 {ECO:0000312|FlyBase:FBgn0103733}; OS Drosophila erecta (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7220; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14021-0224.01; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: Component of the eukaryotic translation initiation CC factor 3 (eIF-3) complex, which is involved in protein synthesis CC of a specialized repertoire of mRNAs and, together with other CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi CC to the 40S ribosome. The eIF-3 complex specifically targets and CC initiates translation of a subset of mRNAs involved in cell CC proliferation. {ECO:0000255|HAMAP-Rule:MF_03005}. CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor CC 3 (eIF-3) complex. The eIF-3 complex interacts with pix. CC {ECO:0000255|HAMAP-Rule:MF_03005}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}. CC -!- SIMILARITY: Belongs to the eIF-3 subunit F family. CC {ECO:0000255|HAMAP-Rule:MF_03005}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH954181; EDV47812.1; -; Genomic_DNA. DR RefSeq; XP_001978854.1; XM_001978818.2. DR ProteinModelPortal; B3P239; -. DR SMR; B3P239; -. DR EnsemblMetazoa; FBtr0131487; FBpp0129979; FBgn0103733. DR GeneID; 6551919; -. DR KEGG; der:Dere_GG11433; -. DR FlyBase; FBgn0103733; Dere\GG11433. DR KO; K03249; -. DR OMA; AVDMEYH; -. DR OrthoDB; EOG091G0EMR; -. DR PhylomeDB; B3P239; -. DR Proteomes; UP000008711; Unassembled WGS sequence. DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:InterPro. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa. DR CDD; cd08064; MPN_eIF3f; 1. DR HAMAP; MF_03005; eIF3f; 1. DR InterPro; IPR027531; eIF3f. DR InterPro; IPR000555; JAMM/MPN+_dom. DR InterPro; IPR024969; Rpn11/EIF3F_C. DR PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1. DR Pfam; PF01398; JAB; 1. DR Pfam; PF13012; MitMem_reg; 1. DR SMART; SM00232; JAB_MPN; 1. DR PROSITE; PS50249; MPN; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis. FT CHAIN 1 280 Eukaryotic translation initiation factor FT 3 subunit F-1. FT /FTId=PRO_0000364299. FT DOMAIN 8 138 MPN. {ECO:0000255|PROSITE- FT ProRule:PRU01182}. SQ SEQUENCE 280 AA; 31105 MW; A860162E65005E57 CRC64; MSALNLTVRV HPVVLFQVVD AFERRNADSH RVIGTLLGSV DKGVVEVTNC FCVPHKEHDD QVEAELSYAL DMYDLNRKVN SNESVVGWWA TGNDVTNHSS VIHEYYAREC NNPVHLTVDT SLQGGRMGLR AYVCIQLGVP GGKSGCMFTP IPVELTSYEP ETFGLKLLQK TVGVSPAHRP KTVPPMLDLA QISEASTKLQ SLLDLILKYV DDVIAHKVTP DNAVGRQLLD LIHSVPHMTH EQFTQMFNAN VRNLLLVITL SQLIKTQLQL NEKLTFLPTA //