ID EI3G2_DROER Reviewed; 273 AA. AC B3NYY7; DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 1. DT 26-FEB-2020, entry version 61. DE RecName: Full=Eukaryotic translation initiation factor 3 subunit G-2 {ECO:0000250|UniProtKB:Q9VDM6}; DE AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006}; DE Short=eIF-3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006}; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-2 {ECO:0000255|HAMAP-Rule:MF_03006}; GN Name=eIF3g2 {ECO:0000250|UniProtKB:Q9VDM6}; GN Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006}, GN eIF3gb {ECO:0000250|UniProtKB:Q9VDM6}; ORFNames=GG23911; OS Drosophila erecta (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7220; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14021-0224.01; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: RNA-binding component of the eukaryotic translation CC initiation factor 3 (eIF-3) complex, which is involved in protein CC synthesis of a specialized repertoire of mRNAs and, together with other CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to CC the 40S ribosome. The eIF-3 complex specifically targets and initiates CC translation of a subset of mRNAs involved in cell proliferation. This CC subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}. CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex. The eIF-3 complex interacts with pix. CC {ECO:0000255|HAMAP-Rule:MF_03006}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. CC -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP- CC Rule:MF_03006}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH954181; EDV48390.1; -; Genomic_DNA. DR RefSeq; XP_001979432.1; XM_001979396.2. DR SMR; B3NYY7; -. DR STRING; 7220.FBpp0142457; -. DR PRIDE; B3NYY7; -. DR EnsemblMetazoa; FBtr0143965; FBpp0142457; FBgn0116050. DR GeneID; 6553721; -. DR KEGG; der:6553721; -. DR HOGENOM; CLU_034595_0_0_1; -. DR KO; K03248; -. DR OMA; MQFIGSK; -. DR OrthoDB; 1226059at2759; -. DR PhylomeDB; B3NYY7; -. DR Proteomes; UP000008711; Unassembled WGS sequence. DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule. DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule. DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule. DR CDD; cd12933; eIF3G; 1. DR CDD; cd12408; RRM_eIF3G_like; 1. DR Gene3D; 3.30.70.330; -; 1. DR HAMAP; MF_03006; eIF3g; 1. DR InterPro; IPR017334; eIF3_g. DR InterPro; IPR024675; eIF3g_N. DR InterPro; IPR034240; eIF3G_RRM. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR Pfam; PF12353; eIF3g; 1. DR Pfam; PF00076; RRM_1; 1. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm; Initiation factor; Protein biosynthesis; RNA-binding. FT CHAIN 1..273 FT /note="Eukaryotic translation initiation factor 3 subunit FT G-2" FT /id="PRO_0000365410" FT DOMAIN 193..271 FT /note="RRM" FT /evidence="ECO:0000255|HAMAP-Rule:MF_03006" SQ SEQUENCE 273 AA; 30458 MW; B88690017114971B CRC64; MKAFNTSWAD EVEADYVDGL PPSNEYIEGD YKYVTEYKFN DDGKKVKVVR TFKIEKQIVP KAVARRRSWV KFGDSLLDKP GPNSQTTMAS EEIFMQFIGS KEFDQTHETQ LDPGKNIAKC RICNGEHWSV NCPYKGTSMD SKTMMETKAN AAAAAAVSDP SKMGKYVPPF MKDGGGGSGG KNWGRGRDRD DSSAVRISNL SESMTEADLE ELVKKIGPHT KMYLAREKNT GLCKGFAYVH FKFRQDAAAA IEVLNGHGYD HLILCVEWSK PQP //