ID EI3G2_DROER Reviewed; 273 AA. AC B3NYY7; DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 1. DT 16-NOV-2011, entry version 22. DE RecName: Full=Eukaryotic translation initiation factor 3 subunit G-2; DE Short=eIF3g-2; DE AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 2; DE Short=eIF-3 RNA-binding subunit 2; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-2; GN Name=eIF3-S4-2; ORFNames=GG23911; OS Drosophila erecta (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7220; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14021-0224.01; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- FUNCTION: Component of the eukaryotic translation initiation CC factor 3 (eIF-3) complex, which is involved in protein synthesis CC and, together with other initiation factors, stimulates binding of CC mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can CC bind 18S rRNA (By similarity). CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor CC 3 (eIF-3) complex. The eIF-3 complex interacts with pix (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable). CC -!- SIMILARITY: Belongs to the eIF-3 subunit G family. CC -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH954181; EDV48390.1; -; Genomic_DNA. DR RefSeq; XP_001979432.1; XM_001979396.1. DR ProteinModelPortal; B3NYY7; -. DR EnsemblMetazoa; FBtr0143965; FBpp0142457; FBgn0116050. DR GeneID; 6553721; -. DR KEGG; der:Dere_GG23911; -. DR FlyBase; FBgn0116050; Dere\GG23911. DR GeneTree; EMGT00050000005294; -. DR OrthoDB; EOG476HG4; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR InterPro; IPR024675; eIF3g_N. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait. DR InterPro; IPR000504; RRM_dom. DR InterPro; IPR017334; Transl_init_eIF-3_G. DR InterPro; IPR001878; Znf_CCHC. DR Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1. DR KO; K03248; -. DR PANTHER; PTHR10352; PTHR10352; 1. DR Pfam; PF12353; eIF3g; 1. DR Pfam; PF00076; RRM_1; 1. DR PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1. DR SMART; SM00360; RRM; 1. DR SMART; SM00343; ZnF_C2HC; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm; Initiation factor; Protein biosynthesis; RNA-binding. FT CHAIN 1 273 Eukaryotic translation initiation factor FT 3 subunit G-2. FT /FTId=PRO_0000365410. FT DOMAIN 193 271 RRM. SQ SEQUENCE 273 AA; 30458 MW; B88690017114971B CRC64; MKAFNTSWAD EVEADYVDGL PPSNEYIEGD YKYVTEYKFN DDGKKVKVVR TFKIEKQIVP KAVARRRSWV KFGDSLLDKP GPNSQTTMAS EEIFMQFIGS KEFDQTHETQ LDPGKNIAKC RICNGEHWSV NCPYKGTSMD SKTMMETKAN AAAAAAVSDP SKMGKYVPPF MKDGGGGSGG KNWGRGRDRD DSSAVRISNL SESMTEADLE ELVKKIGPHT KMYLAREKNT GLCKGFAYVH FKFRQDAAAA IEVLNGHGYD HLILCVEWSK PQP //