ID B3KXJ2_HUMAN Unreviewed; 221 AA. AC B3KXJ2; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 24-JUL-2024, entry version 63. DE SubName: Full=cDNA FLJ45536 fis, clone BRTHA2031917, highly similar to Ciliary neurotrophic factor receptor alpha {ECO:0000313|EMBL:BAG54504.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG54504.1}; RN [1] {ECO:0000313|EMBL:BAG54504.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Thalamus {ECO:0000313|EMBL:BAG54504.1}; RA Ota T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Sugiyama T., RA Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., RA Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K., RA Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., RA Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., RA Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor CC {ECO:0000256|ARBA:ARBA00004589}. CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 CC subfamily. {ECO:0000256|ARBA:ARBA00010890}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK127444; BAG54504.1; -; mRNA. DR AlphaFoldDB; B3KXJ2; -. DR SMR; B3KXJ2; -. DR PeptideAtlas; B3KXJ2; -. DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IEA:TreeGrafter. DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IEA:TreeGrafter. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0004897; F:ciliary neurotrophic factor receptor activity; IEA:TreeGrafter. DR GO; GO:0019955; F:cytokine binding; IEA:TreeGrafter. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR050379; Type-I_Cytokine_Rcpt. DR PANTHER; PTHR23036:SF21; CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA; 1. DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1. DR Pfam; PF00041; fn3; 1. DR SMART; SM00060; FN3; 1. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR PROSITE; PS50853; FN3; 1. DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1. PE 2: Evidence at transcript level; KW Receptor {ECO:0000313|EMBL:BAG54504.1}. FT DOMAIN 55..155 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT REGION 150..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 161..179 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 221 AA; 24078 MW; FFCF52BF11E9EE68 CRC64; MVCEKDPALK NRCHIRYMHL FSTIKYKVSI SVSNALGHNA TAITFDEFTI VKPDPPENVV ARPVPSNPRR LEVTWQTPST WPDPESFPLK FFLRYRPLIL DQWQHVELSD GTAHTITDAY AGKEYIIQVA AKDNEIGTWS DWSVAAHATP WTEEPRHLTT EAQAAETTTS TTSSLAPPPT TKICDPGELG SGGGPSAPFL VSVPITLALA AAAATASSLL I //