ID B3KW46_HUMAN Unreviewed; 512 AA. AC B3KW46; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 29-MAY-2024, entry version 72. DE RecName: Full=Scavenger receptor class B member 1 {ECO:0000256|ARBA:ARBA00040821}; DE AltName: Full=SR-BI {ECO:0000256|ARBA:ARBA00042244}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG54008.1}; RN [1] {ECO:0000313|EMBL:BAG54008.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAG54008.1}; RA Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M., RA Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H., RA Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., RA Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., RA Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A., RA Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., RA Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane, caveola CC {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004189}. CC -!- SIMILARITY: Belongs to the CD36 family. CC {ECO:0000256|ARBA:ARBA00010532}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK124112; BAG54008.1; -; mRNA. DR AlphaFoldDB; B3KW46; -. DR MaxQB; B3KW46; -. DR PeptideAtlas; B3KW46; -. DR ProteomicsDB; 3776; -. DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0008289; F:lipid binding; IEA:TreeGrafter. DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:TreeGrafter. DR GO; GO:0005044; F:scavenger receptor activity; IEA:TreeGrafter. DR GO; GO:0033344; P:cholesterol efflux; IEA:TreeGrafter. DR GO; GO:0070508; P:cholesterol import; IEA:TreeGrafter. DR GO; GO:0034381; P:plasma lipoprotein particle clearance; IEA:TreeGrafter. DR GO; GO:0043654; P:recognition of apoptotic cell; IEA:TreeGrafter. DR InterPro; IPR005428; CD36/SCARB1/SNMP1. DR InterPro; IPR002159; CD36_fam. DR PANTHER; PTHR11923:SF96; SCAVENGER RECEPTOR CLASS B MEMBER 1; 1. DR PANTHER; PTHR11923; SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1; 1. DR Pfam; PF01130; CD36; 1. DR PRINTS; PR01610; CD36ANTIGEN. DR PRINTS; PR01609; CD36FAMILY. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR605428-53}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:BAG54008.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 402..423 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DISULFID 210..343 FT /evidence="ECO:0000256|PIRSR:PIRSR605428-53" SQ SEQUENCE 512 AA; 56884 MW; 09E557EBD0C66996 CRC64; MNVRIDPSSL SFNMWKEIPI PFYLSVYFFD VMNPSEILKG EKPQVRERGP YVYREFRHKS NITFNNNDTV SFLEYRTFQF QPSKSHGSES DYIVMPNILV LGAAVMMENK PMTLKLIMTL AFTTLGERAF MNRTVGEIMW GYKDPLVNLI NKYFPGMFPF KDKFGLFAEL NNSDSGLFTV FTGVQNISRI HLVDKWNGLS KVDFWHSDQC NMINGTSGQM WPPFMTPESS LEFYSPEACR SMKLMYKESG VFEGIPTYRF VAPKTLFANG SIYPPNEGFC PCLESGIQNV STCRFSAPLF LSHPHFLNAD PVLAEAVTGL HPNQEAHSLF LDIHPVTGIP MNCSVKLQLS LYMKSVAGIG QTGKIEPVVL PLLWFAESGA MEGETLHTFY TQLVLMPKVM HYAQYVLLAL GCVLLLVPVI CQIRSQVGAG QRAARADSHS LACWGKGASD RTLWPTAAWS PPPAAVLRLC RSGSGHCWGL RSTLASFACR VATTLPVLEG LGPSLGGGTG GL //