ID B3KTV0_HUMAN Unreviewed; 621 AA. AC B3KTV0; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 02-OCT-2024, entry version 65. DE RecName: Full=Heat shock cognate 71 kDa protein {ECO:0000256|ARBA:ARBA00040611}; DE EC=3.6.4.10 {ECO:0000256|ARBA:ARBA00012554}; DE AltName: Full=Heat shock 70 kDa protein 8 {ECO:0000256|ARBA:ARBA00042369}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53212.1}; RN [1] {ECO:0000313|EMBL:BAG53212.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver {ECO:0000313|EMBL:BAG53212.1}; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., RA Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; CC Evidence={ECO:0000256|ARBA:ARBA00001629}; CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096100; BAG53212.1; -; mRNA. DR AlphaFoldDB; B3KTV0; -. DR IntAct; B3KTV0; 1. DR MINT; B3KTV0; -. DR GO; GO:0005776; C:autophagosome; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005764; C:lysosome; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0099524; C:postsynaptic cytosol; IEA:TreeGrafter. DR GO; GO:0099523; C:presynaptic cytosol; IEA:TreeGrafter. DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. DR GO; GO:0043195; C:terminal bouton; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro. DR GO; GO:1990833; F:clathrin-uncoating ATPase activity; IEA:TreeGrafter. DR GO; GO:1904764; P:chaperone-mediated autophagy translocation complex disassembly; IEA:TreeGrafter. DR GO; GO:0061738; P:late endosomal microautophagy; IEA:TreeGrafter. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0061740; P:protein targeting to lysosome involved in chaperone-mediated autophagy; IEA:TreeGrafter. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR GO; GO:1990832; P:slow axonal transport; IEA:TreeGrafter. DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1. DR Gene3D; 1.20.1270.10; -; 1. DR Gene3D; 3.30.420.40; -; 2. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR018181; Heat_shock_70_CS. DR InterPro; IPR029048; HSP70_C_sf. DR InterPro; IPR029047; HSP70_peptide-bd_sf. DR InterPro; IPR013126; Hsp_70_fam. DR PANTHER; PTHR19375:SF379; HEAT SHOCK COGNATE 71 KDA PROTEIN; 1. DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1. DR Pfam; PF00012; HSP70; 2. DR PRINTS; PR00301; HEATSHOCK70. DR SUPFAM; SSF53067; Actin-like ATPase domain; 2. DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1. DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1. DR PROSITE; PS00297; HSP70_1; 1. DR PROSITE; PS00329; HSP70_2; 1. DR PROSITE; PS01036; HSP70_3; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU003322}; KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}; KW Stress response {ECO:0000313|EMBL:BAG53212.1}. FT REGION 589..621 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 621 AA; 67980 MW; 42BB40ADED19790F CRC64; MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA MNPTNTVMVV NDAGRPKVQV EYKGETKSFY PEEVSSMVLT KMKEIAEAYL GKTVTNAVVT VPAYFNDSQR QATKDAGTIA GLNVLRIINE PTAAAIAYGL DKKVGAERNV LIFDLGGGTF DVSILTIEDG IFEVKSTAGD THLGGEDFDN RMVNHFIAEF KRKHKKDISE NKRAVRRLRT ACERAKRTLS SSTQASIEID SLYEGIDFYT SITRARFEEL NADLFRGTLD PVEKALRDAK LDKSQIHDIV LVGGSTRIPK IQKLLQDFFN GKELNKSINP DEAVAYGAAV QAAILSGDKS ENVQDLLLLD VTPLSLGIET AGGVMTVLIK RNTTIPTKQT QTFTTYSDNQ PGVLIQVYEG ERAMTKDNNL LGKFELTGIP PAPRGVPQIE VTFDIDANGI LNVSAVDKST GKENKITITN DKGRLSKEDI ERMVQEAEKY KAEDEKQRDK VSSKNSLESY AFNMKATVED EKLQGKINDE DKQKILDKCN EIINWLDKNQ TAEKEEFEHQ QKELEKVCNP IITKLYQSAG GMPGGMPGGF PGGGAPPSGG ASSRPTIEEV D //