ID B3KQV6_HUMAN Unreviewed; 410 AA. AC B3KQV6; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 12-OCT-2022, entry version 100. DE SubName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform {ECO:0000313|Ensembl:ENSP00000470504}; DE SubName: Full=cDNA FLJ33169 fis, clone ADRGL2000384, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform {ECO:0000313|EMBL:BAG52168.1}; GN Name=PPP2R1A {ECO:0000313|Ensembl:ENSP00000470504}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG52168.1}; RN [1] {ECO:0000313|EMBL:BAG52168.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Adrenal gland {ECO:0000313|EMBL:BAG52168.1}; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., RA Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000470504, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [3] {ECO:0007829|PubMed:19608861} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [4] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000470504} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. RN [6] {ECO:0007829|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0007829|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010320; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK090488; BAG52168.1; -; mRNA. DR RefSeq; XP_016882418.1; XM_017026929.1. DR SMR; B3KQV6; -. DR SwissPalm; B3KQV6; -. DR MaxQB; B3KQV6; -. DR PRIDE; B3KQV6; -. DR Antibodypedia; 4348; 390 antibodies from 41 providers. DR Ensembl; ENST00000462990.5; ENSP00000470504.1; ENSG00000105568.18. DR UCSC; uc002pyq.4; human. DR HGNC; HGNC:9302; PPP2R1A. DR VEuPathDB; HostDB:ENSG00000105568; -. DR GeneTree; ENSGT00950000183066; -. DR HOGENOM; CLU_015533_2_2_1; -. DR BioGRID-ORCS; 5518; 685 hits in 1097 CRISPR screens. DR ChiTaRS; PPP2R1A; human. DR GenomeRNAi; 5518; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000105568; Expressed in cortical plate and 197 other tissues. DR ExpressionAtlas; B3KQV6; baseline and differential. DR GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro. DR GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro. DR Gene3D; 1.25.10.10; -; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000357; HEAT. DR InterPro; IPR021133; HEAT_type_2. DR InterPro; IPR031090; PP2A_A_meta. DR PANTHER; PTHR10648:SF2; PTHR10648:SF2; 1. DR Pfam; PF02985; HEAT; 3. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS50077; HEAT_REPEAT; 8. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:B3KQV6, KW ECO:0007829|MaxQB:B3KQV6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REPEAT 26..64 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 65..103 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 104..141 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 147..185 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 186..224 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 225..263 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 342..380 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" FT REPEAT 381..410 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" SQ SEQUENCE 410 AA; 45604 MW; 2AF05E07964A193F CRC64; MVRRAAASKL GEFAKVLELD NVKSEIIPMF SNLASDEQDS VRLLAVEACV NIAQLLPQED LEALVMPTLR QAAEDKSWRV RYMVADKFTE LQKAVGPEIT KTDLVPAFQN LMKDCEAEVR AAASHKVKEF CENLSADCRE NVIMSQILPC IKELVSDANQ HVKSALASVI MGLSPILGKD NTIEHLLPLF LAQLKDECPE VRLNIISNLD CVNEVIGIRQ LSQSLLPAIV ELAEDAKWRV RLAIIEYMPL LAGQLGVEFF DEKLNSLCMA WLVDHVYAIR EAATSNLKKL VEKFGKEWAH ATIIPKVLAM SGDPNYLHRM TTLFCINVLS EVCGQDITTK HMLPTVLRMA GDPVANVRFN VAKSLQKIGP ILDNSTLQSE VKPILEKLTQ DQDVDVKYFA QEALTVLSLA //