ID B3F6B5_BOVIN Unreviewed; 264 AA. AC B3F6B5; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 24-JAN-2024, entry version 70. DE RecName: Full=Major prion protein {ECO:0000256|RuleBase:RU003882}; GN Name=PRNP {ECO:0000313|EMBL:ABU98047.1}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ABU98047.1}; RN [1] {ECO:0000313|EMBL:ABU98047.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=50-0039-3 {ECO:0000313|EMBL:ABU98047.1}; RX PubMed=18096956; RA Brunelle B.W., Kehrli M.E.Jr., Stabel J.R., Spurlock D.M., Hansen L.B., RA Nicholson E.M.; RT "Short communication: Allele, genotype, and haplotype data for bovine RT spongiform encephalopathy-resistance polymorphisms from healthy US Holstein RT cattle."; RL J. Dairy Sci. 91:338-342(2008). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Golgi CC apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor CC {ECO:0000256|ARBA:ARBA00004589}. CC -!- SIMILARITY: Belongs to the prion family. CC {ECO:0000256|ARBA:ARBA00009910, ECO:0000256|RuleBase:RU003882}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF626285; ABU98047.1; -; Genomic_DNA. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW. DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro. DR Gene3D; 1.10.790.10; Prion/Doppel protein, beta-ribbon domain; 1. DR InterPro; IPR000817; Prion. DR InterPro; IPR036924; Prion/Doppel_b-ribbon_dom_sf. DR InterPro; IPR022416; Prion/Doppel_prot_b-ribbon_dom. DR InterPro; IPR025860; Prion_N_dom. DR PANTHER; PTHR15506; DOPPEL PRION; 1. DR PANTHER; PTHR15506:SF2; MAJOR PRION PROTEIN; 1. DR Pfam; PF00377; Prion; 1. DR Pfam; PF11587; Prion_bPrPp; 1. DR PRINTS; PR00341; PRION. DR SMART; SM00157; PRP; 1. DR SUPFAM; SSF54098; Prion-like; 1. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. PE 3: Inferred from homology; KW Amyloid {ECO:0000256|ARBA:ARBA00023087}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU003882}; Copper {ECO:0000256|ARBA:ARBA00023008}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003882}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Prion {ECO:0000256|ARBA:ARBA00022678, ECO:0000256|RuleBase:RU003882}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT TRANSMEM 6..24 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 122..142 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 243..263 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 124..139 FT /note="Prion/Doppel protein beta-ribbon" FT /evidence="ECO:0000259|PROSITE:PS00291" FT DOMAIN 211..229 FT /note="Prion/Doppel protein beta-ribbon" FT /evidence="ECO:0000259|PROSITE:PS00706" FT REGION 24..118 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 264 AA; 28668 MW; 751470504574A54C CRC64; MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGXW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQPHGGGG WGQGGTHGQW NKPSKPKTNM KHVAGAAAAG AVVGGLGGYM LGSAMSRPLI HFGSDYEDRY YRENMHRYPN QVYYRPVDQY SNQNNFVHDC VNITVKEHTV TTTTKGENFT ETDIKMMERV VEQMCITQYQ RESQAYYQRG ASVILFSSPP VILLISFLIF LIVG //