ID AROC_METI4 Reviewed; 366 AA. AC B3DXL0; DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 1. DT 25-JAN-2012, entry version 26. DE RecName: Full=Chorismate synthase; DE EC=4.2.3.5; DE AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase; GN Name=aroC; OrderedLocusNames=Minf_0184; OS Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum OS (strain V4)). OC Bacteria; Verrucomicrobia; unclassified Verrucomicrobia; OC Methylacidiphilales; Methylacidiphilaceae; Methylacidiphilum. OX NCBI_TaxID=481448; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate V4; RX PubMed=18593465; DOI=10.1186/1745-6150-3-26; RA Hou S., Makarova K.S., Saw J.H., Senin P., Ly B.V., Zhou Z., Ren Y., RA Wang J., Galperin M.Y., Omelchenko M.V., Wolf Y.I., Yutin N., RA Koonin E.V., Stott M.B., Mountain B.W., Crowe M.A., Smirnova A.V., RA Dunfield P.F., Feng L., Wang L., Alam M.; RT "Complete genome sequence of the extremely acidophilic methanotroph RT isolate V4, Methylacidiphilum infernorum, a representative of the RT bacterial phylum Verrucomicrobia."; RL Biol. Direct 3:26-26(2008). CC -!- CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = CC chorismate + phosphate. CC -!- COFACTOR: Reduced flavin (By similarity). CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and CC phosphoenolpyruvate: step 7/7. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SIMILARITY: Belongs to the chorismate synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000975; ACD82244.1; -; Genomic_DNA. DR RefSeq; YP_001938843.1; NC_010794.1. DR ProteinModelPortal; B3DXL0; -. DR STRING; B3DXL0; -. DR GeneID; 6351099; -. DR GenomeReviews; CP000975_GR; Minf_0184. DR KEGG; min:Minf_0184; -. DR PATRIC; 22489363; VBIMetInf111569_0192. DR HOGENOM; HBG292336; -. DR OMA; GVQGGIS; -. DR ProtClustDB; PRK05382; -. DR GO; GO:0004107; F:chorismate synthase activity; IEA:EC. DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW. DR HAMAP; MF_00300; Chorismate_synth; 1; -. DR InterPro; IPR000453; Chorismate_synth. DR InterPro; IPR020541; Chorismate_synthase_CS. DR KO; K01736; -. DR PANTHER; PTHR21085; Chorismate_synth; 1. DR Pfam; PF01264; Chorismate_synt; 1. DR PIRSF; PIRSF001456; Chorismate_synth; 1. DR SUPFAM; SSF103263; Chorismate_synth; 1. DR TIGRFAMs; TIGR00033; AroC; 1. DR PROSITE; PS00787; CHORISMATE_SYNTHASE_1; 1. DR PROSITE; PS00788; CHORISMATE_SYNTHASE_2; 1. DR PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; KW Complete proteome; Lyase. FT CHAIN 1 366 Chorismate synthase. FT /FTId=PRO_1000115369. SQ SEQUENCE 366 AA; 40267 MW; F6177B82EB3FA3DB CRC64; MPNTFGHLFR ITTWGESHGK GVGVVIDGCP PRIPLSEEDI QKELDRRRPG QSKITTQRKE RDIAAILSGT FNGMTLGTPI MIWVKNEDAR PEAYAEMEKI YRPSHADFTY QAKYGIRNWQ GGGRSSARET IGRVAGGAVG GKVLQFLYPE IEVIAWVSEV HGLKSLCDPN TVTREDVESN ILRWPNAENL GEALKEIERA QKEGDTVGGI VECIVRGMPV GLGEPVFDKL EADLAKAMLS LPASKGFEIG SGFRGALMRG SEHNDPFYME GNKVRTKTNW SGGVQGGISN GENLYFRVAF KPVATIAQEQ QTVSVDGEEV ILRARGRHDP CVLPRAVPIV EAMTKLVLVD HALRQKAIEL TPRSFS //