ID B3DHC5_DANRE Unreviewed; 255 AA. AC B3DHC5; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 27-MAY-2015, entry version 53. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000093966}; DE SubName: Full=Zgc:194131 {ECO:0000313|EMBL:AAI62715.1}; GN Name=apoa4b.2 {ECO:0000313|ZFIN:ZDB-GENE-030131-3143}; GN ORFNames=zgc:194131 {ECO:0000313|EMBL:AAI62715.1, GN ECO:0000313|Ensembl:ENSDARP00000093966}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62715.1, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|EMBL:AAI62715.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000093966} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000093966, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00143437}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX004983; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC162715; AAI62715.1; -; mRNA. DR EMBL; BC162716; AAI62716.1; -; mRNA. DR RefSeq; NP_001122230.1; NM_001128758.1. DR UniGene; Dr.159496; -. DR Ensembl; ENSDART00000103190; ENSDARP00000093966; ENSDARG00000020866. DR Ensembl; ENSDART00000142168; ENSDARP00000114649; ENSDARG00000020866. DR GeneID; 570354; -. DR CTD; 570354; -. DR ZFIN; ZDB-GENE-030131-3143; apoa4b.2. DR eggNOG; NOG42418; -. DR GeneTree; ENSGT00530000063081; -. DR HOGENOM; HOG000063678; -. DR HOVERGEN; HBG107479; -. DR OMA; RLDPYAQ; -. DR OrthoDB; EOG70GMGG; -. DR PhylomeDB; B3DHC5; -. DR TreeFam; TF334458; -. DR NextBio; 20890096; -. DR Proteomes; UP000000437; Chromosome 16. DR GO; GO:0072562; C:blood microparticle; IBA:GO_Central. DR GO; GO:0042627; C:chylomicron; IBA:GO_Central. DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central. DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central. DR GO; GO:0017127; F:cholesterol transporter activity; IBA:GO_Central. DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central. DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central. DR GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central. DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central. DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central. DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central. DR GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central. DR GO; GO:0031102; P:neuron projection regeneration; IBA:GO_Central. DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central. DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central. DR GO; GO:0010873; P:positive regulation of cholesterol esterification; IBA:GO_Central. DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central. DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central. DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central. DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central. DR GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central. DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central. DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central. DR InterPro; IPR000074; ApoA_E. DR Pfam; PF01442; Apolipoprotein; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Lipid transport {ECO:0000256|SAAS:SAAS00143435}; KW Proteomics identification {ECO:0000213|PeptideAtlas:B3DHC5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Secreted {ECO:0000256|SAAS:SAAS00143438}; KW Transport {ECO:0000256|SAAS:SAAS00143436}. SQ SEQUENCE 255 AA; 29384 MW; 94E4385541269D82 CRC64; MKVLVVFALA VFTGCQANLF YADEPKPQLE QLTDAFWSYV SKATQTAEET VKMIRESQLG QEVNERLTQS ADMASEYAVV LKKQVDPLTE ELMNKITKET EVLRERLGQD LINVREKLEP YADNMKSQIQ QRVEELRAAM APYADSLDSE TLKATLLQKS EELRGNLEQS VKELQVQLEP YTAELKEKVD QHLQEFQKTV TPLTEDLQVQ IRERAQMVQQ SLTPYAEDLK EKLDPYAQNL KDQLASLYES YTKRN //