ID B3DHC5_DANRE Unreviewed; 255 AA. AC B3DHC5; B3DHC6; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 02-OCT-2024, entry version 123. DE RecName: Full=Apolipoprotein A-IV {ECO:0000256|ARBA:ARBA00041197}; DE AltName: Full=Apolipoprotein A4 {ECO:0000256|ARBA:ARBA00042591}; GN Name=apoa4b.2 {ECO:0000313|Ensembl:ENSDARP00000093966, GN ECO:0000313|RefSeq:NP_001122230.1, ECO:0000313|RefSeq:XP_021322408.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-3143}; GN Synonyms=fc28d04 {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}, wu:fc10a03 GN {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}, wu:fc28d04 GN {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}; GN ORFNames=zgc:194131 {ECO:0000313|EMBL:AAI62716.1, GN ECO:0000313|RefSeq:NP_001122230.1, ECO:0000313|RefSeq:XP_021322408.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62716.1}; RN [1] {ECO:0000313|EMBL:AAI62716.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000093966} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000093966, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [4] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25633982; DOI=10.1242/dmm.018754; RA Otis J.P., Zeituni E.M., Thierer J.H., Anderson J.L., Brown A.C., RA Boehm E.D., Cerchione D.M., Ceasrine A.M., Avraham-Davidi I., Tempelhof H., RA Yaniv K., Farber S.A.; RT "Zebrafish as a model for apolipoprotein biology: comprehensive expression RT analysis and a role for ApoA-IV in regulating food intake."; RL Dis. Model. Mech. 8:295-309(2015). RN [5] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25756310; RA Chatzopoulou A., Roy U., Meijer A.H., Alia A., Spaink H.P., Schaaf M.J.; RT "Transcriptional and metabolic effects of glucocorticoid receptor alpha and RT beta signaling in zebrafish."; RL Endocrinology 156:1757-1769(2015). RN [6] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [7] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27655916; RA Zeituni E.M., Wilson M.H., Zheng X., Iglesias P.A., Sepanski M.A., RA Siddiqi M.A., Anderson J.L., Zheng Y., Farber S.A.; RT "Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology RT and Lipid-dependent Transcriptional Responses."; RL J. Biol. Chem. 291:23804-23816(2016). RN [8] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27731423; RA Skjaerven K.H., Jakt L.M., Dahl J.A., Espe M., Aanes H., Hamre K., RA Fernandes J.M.; RT "Parental vitamin deficiency affects the embryonic gene expression of RT immune-, lipid transport- and apolipoprotein genes."; RL Sci. Rep. 6:34535-34535(2016). RN [9] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28888875; RA Jin C., Luo T., Zhu Z., Pan Z., Yang J., Wang W., Fu Z., Jin Y.; RT "Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism RT disorder in zebrafish."; RL Comp. Biochem. Physiol. C Toxicol. Pharmacol. 202:85-93(2017). RN [10] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28631837; RA Shi W.J., Zhao J.L., Jiang Y.X., Huang G.Y., Liu Y.S., Zhang J.N., RA Ying G.G.; RT "Transcriptional and histological alterations in gonad of adult zebrafish RT after exposure to the synthetic progestin norgestrel."; RL Environ. Toxicol. Chem. 36:3267-3276(2017). RN [11] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29209275; DOI=10.3389/fendo.2017.00319; RA Quinlivan V.H., Farber S.A.; RT "Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish."; RL Front. Endocrinol. 8:319-319(2017). RN [12] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [13] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29445184; RA Skjaerven K.H., Jakt L.M., Fernandes J.M.O., Dahl J.A., Adam A.C., RA Klughammer J., Bock C., Espe M.; RT "Parental micronutrient deficiency distorts liver DNA methylation and RT expression of lipid genes associated with a fatty-liver-like phenotype in RT offspring."; RL Sci. Rep. 8:3055-3055(2018). RN [14] {ECO:0000313|RefSeq:NP_001122230.1, ECO:0000313|RefSeq:XP_021322408.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021322408.1}; RG RefSeq; RL Submitted (JUN-2024) to UniProtKB. CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}. CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family. CC {ECO:0000256|ARBA:ARBA00008788}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX004983; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC162715; AAI62715.1; -; mRNA. DR EMBL; BC162716; AAI62716.1; -; mRNA. DR RefSeq; NP_001122230.1; NM_001128758.1. DR RefSeq; XP_021322408.1; XM_021466733.1. DR STRING; 7955.ENSDARP00000093966; -. DR PaxDb; 7955-ENSDARP00000114649; -. DR Ensembl; ENSDART00000103190.5; ENSDARP00000093966.3; ENSDARG00000020866.10. DR Ensembl; ENSDART00000142168.2; ENSDARP00000114649.1; ENSDARG00000020866.10. DR GeneID; 570354; -. DR KEGG; dre:570354; -. DR AGR; ZFIN:ZDB-GENE-030131-3143; -. DR CTD; 570354; -. DR ZFIN; ZDB-GENE-030131-3143; apoa4b.2. DR eggNOG; ENOG502QSC5; Eukaryota. DR OMA; QPYTENM; -. DR OrthoDB; 4600760at2759; -. DR TreeFam; TF334458; -. DR Proteomes; UP000000437; Chromosome 16. DR Bgee; ENSDARG00000020866; Expressed in intestine and 17 other cell types or tissues. DR GO; GO:0042627; C:chylomicron; IBA:GO_Central. DR GO; GO:1903561; C:extracellular vesicle; IBA:GO_Central. DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central. DR GO; GO:0034362; C:low-density lipoprotein particle; IBA:GO_Central. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central. DR GO; GO:0120020; F:cholesterol transfer activity; IBA:GO_Central. DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central. DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central. DR GO; GO:0055090; P:acylglycerol homeostasis; IBA:GO_Central. DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central. DR GO; GO:0008203; P:cholesterol metabolic process; IBA:GO_Central. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central. DR Gene3D; 1.20.5.20; -; 2. DR Gene3D; 1.20.120.20; Apolipoprotein; 1. DR InterPro; IPR000074; ApoA_E. DR InterPro; IPR050163; Apolipoprotein_A1/A4/E. DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1. DR PANTHER; PTHR18976:SF1; APOLIPOPROTEIN A-IV; 1. DR Pfam; PF01442; Apolipoprotein; 1. DR SUPFAM; SSF58113; Apolipoprotein A-I; 1. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|PeptideAtlas:B3DHC5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001122230.1}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 18..255 FT /note="Apolipoprotein A-IV" FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001122230.1" FT /id="PRO_5035034999" SQ SEQUENCE 255 AA; 29384 MW; 94E4385541269D82 CRC64; MKVLVVFALA VFTGCQANLF YADEPKPQLE QLTDAFWSYV SKATQTAEET VKMIRESQLG QEVNERLTQS ADMASEYAVV LKKQVDPLTE ELMNKITKET EVLRERLGQD LINVREKLEP YADNMKSQIQ QRVEELRAAM APYADSLDSE TLKATLLQKS EELRGNLEQS VKELQVQLEP YTAELKEKVD QHLQEFQKTV TPLTEDLQVQ IRERAQMVQQ SLTPYAEDLK EKLDPYAQNL KDQLASLYES YTKRN //