ID B3DHC5_DANRE Unreviewed; 255 AA. AC B3DHC5; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 03-AUG-2022, entry version 111. DE SubName: Full=Zgc:194131 {ECO:0000313|EMBL:AAI62716.1}; DE SubName: Full=apolipoprotein A-IV-like isoform X2 {ECO:0000313|RefSeq:XP_021322408.1}; DE SubName: Full=apolipoprotein A-IV-like precursor {ECO:0000313|RefSeq:NP_001122230.1}; GN Name=fc28d04 {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}; GN Synonyms=wu:fc10a03 {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}, wu:fc28d04 GN {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1}; GN OrderedLocusNames=apoa4b.2 {ECO:0000313|RefSeq:NP_001122230.1, GN ECO:0000313|RefSeq:XP_021322408.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-3143}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-030131-3143}, GN zgc:194131 {ECO:0000313|EMBL:AAI62716.1, GN ECO:0000313|RefSeq:NP_001122230.1, ECO:0000313|RefSeq:XP_021322408.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62716.1}; RN [1] {ECO:0000313|EMBL:AAI62716.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25633982; RA Otis J.P., Zeituni E.M., Thierer J.H., Anderson J.L., Brown A.C., RA Boehm E.D., Cerchione D.M., Ceasrine A.M., Avraham-Davidi I., Tempelhof H., RA Yaniv K., Farber S.A.; RT "Zebrafish as a model for apolipoprotein biology: comprehensive expression RT analysis and a role for ApoA-IV in regulating food intake."; RL Dis. Model. Mech. 8:295-309(2015). RN [3] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25756310; RA Chatzopoulou A., Roy U., Meijer A.H., Alia A., Spaink H.P., Schaaf M.J.; RT "Transcriptional and metabolic effects of glucocorticoid receptor alpha and RT beta signaling in zebrafish."; RL Endocrinology 156:1757-1769(2015). RN [4] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [5] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27655916; RA Zeituni E.M., Wilson M.H., Zheng X., Iglesias P.A., Sepanski M.A., RA Siddiqi M.A., Anderson J.L., Zheng Y., Farber S.A.; RT "Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology RT and Lipid-dependent Transcriptional Responses."; RL J. Biol. Chem. 291:23804-23816(2016). RN [6] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27731423; RA Skjaerven K.H., Jakt L.M., Dahl J.A., Espe M., Aanes H., Hamre K., RA Fernandes J.M.; RT "Parental vitamin deficiency affects the embryonic gene expression of RT immune-, lipid transport- and apolipoprotein genes."; RL Sci. Rep. 6:34535-34535(2016). RN [7] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28888875; RA Jin C., Luo T., Zhu Z., Pan Z., Yang J., Wang W., Fu Z., Jin Y.; RT "Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism RT disorder in zebrafish."; RL Comp. Biochem. Physiol. C Toxicol. Pharmacol. 202:85-93(2017). RN [8] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28631837; RA Shi W.J., Zhao J.L., Jiang Y.X., Huang G.Y., Liu Y.S., Zhang J.N., RA Ying G.G.; RT "Transcriptional and histological alterations in gonad of adult zebrafish RT after exposure to the synthetic progestin norgestrel."; RL Environ. Toxicol. Chem. 36:3267-3276(2017). RN [9] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29209275; DOI=10.3389/fendo.2017.00319; RA Quinlivan V.H., Farber S.A.; RT "Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish."; RL Front. Endocrinol. 8:319-319(2017). RN [10] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [11] {ECO:0000313|RefSeq:NP_001122230.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29445184; RA Skjaerven K.H., Jakt L.M., Fernandes J.M.O., Dahl J.A., Adam A.C., RA Klughammer J., Bock C., Espe M.; RT "Parental micronutrient deficiency distorts liver DNA methylation and RT expression of lipid genes associated with a fatty-liver-like phenotype in RT offspring."; RL Sci. Rep. 8:3055-3055(2018). RN [12] {ECO:0000313|RefSeq:NP_001122230.1, ECO:0000313|RefSeq:XP_021322408.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021322408.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family. CC {ECO:0000256|ARBA:ARBA00008788}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC162716; AAI62716.1; -; mRNA. DR RefSeq; NP_001122230.1; NM_001128758.1. DR RefSeq; XP_021322408.1; XM_021466733.1. DR STRING; 7955.ENSDARP00000114649; -. DR GeneID; 570354; -. DR KEGG; dre:570354; -. DR CTD; 570354; -. DR ZFIN; ZDB-GENE-030131-3143; apoa4b.2. DR ZFIN; ZDB-GENE-030131-3143; SO:0001217. DR eggNOG; ENOG502QSC5; Eukaryota. DR GeneTree; ENSGT00950000182929; -. DR OMA; QPYTENM; -. DR OrthoDB; 1299087at2759; -. DR TreeFam; TF334458; -. DR Reactome; R-DRE-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). DR Reactome; R-DRE-8957275; Post-translational protein phosphorylation. DR Reactome; R-DRE-8963888; Chylomicron assembly. DR Reactome; R-DRE-975634; Retinoid metabolism and transport. DR Proteomes; UP000000437; Chromosome 16. DR Bgee; ENSDARG00000020866; Expressed in intestine and 17 other tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008289; F:lipid binding; IEA:InterPro. DR GO; GO:0006869; P:lipid transport; IEA:InterPro. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR InterPro; IPR000074; ApoA_E. DR Pfam; PF01442; Apolipoprotein; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|PeptideAtlas:B3DHC5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001122230.1}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 18..255 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001122230.1" FT /id="PRO_5035034999" SQ SEQUENCE 255 AA; 29384 MW; 94E4385541269D82 CRC64; MKVLVVFALA VFTGCQANLF YADEPKPQLE QLTDAFWSYV SKATQTAEET VKMIRESQLG QEVNERLTQS ADMASEYAVV LKKQVDPLTE ELMNKITKET EVLRERLGQD LINVREKLEP YADNMKSQIQ QRVEELRAAM APYADSLDSE TLKATLLQKS EELRGNLEQS VKELQVQLEP YTAELKEKVD QHLQEFQKTV TPLTEDLQVQ IRERAQMVQQ SLTPYAEDLK EKLDPYAQNL KDQLASLYES YTKRN //