ID B3DGG4_DANRE Unreviewed; 800 AA. AC B3DGG4; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 04-FEB-2015, entry version 52. DE SubName: Full=Cadherin 11, osteoblast {ECO:0000313|EMBL:AAI63442.1}; DE SubName: Full=Cdh11 protein {ECO:0000313|EMBL:AAI62388.1}; DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000006449}; GN Name=cdh11 {ECO:0000313|EMBL:AAI62388.1, GN ECO:0000313|Ensembl:ENSDARP00000006449, GN ECO:0000313|ZFIN:ZDB-GENE-980526-170}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62388.1}; RN [1] {ECO:0000313|EMBL:AAI62388.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000006449} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000006449}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000006449, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000006449, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- FUNCTION: Cadherins are calcium dependent cell adhesion proteins. CC {ECO:0000256|RuleBase:RU004357}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS00167213}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00167213}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003318}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU003318}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CT025913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC162388; AAI62388.1; -; mRNA. DR EMBL; BC162403; AAI62403.1; -; mRNA. DR EMBL; BC163442; AAI63442.1; -; mRNA. DR RefSeq; NP_571289.1; NM_131214.1. DR RefSeq; XP_005166503.1; XM_005166446.2. DR UniGene; Dr.251; -. DR STRING; 7955.ENSDARP00000006449; -. DR Ensembl; ENSDART00000002279; ENSDARP00000006449; ENSDARG00000021442. DR GeneID; 30461; -. DR KEGG; dre:30461; -. DR CTD; 1009; -. DR ZFIN; ZDB-GENE-980526-170; cdh11. DR GeneTree; ENSGT00760000118954; -. DR HOGENOM; HOG000231252; -. DR HOVERGEN; HBG005217; -. DR KO; K06803; -. DR OMA; HENYHAN; -. DR PhylomeDB; B3DGG4; -. DR TreeFam; TF329887; -. DR Reactome; REACT_227013; Adherens junctions interactions. DR NextBio; 20806855; -. DR PRO; PR:B3DGG4; -. DR Proteomes; UP000000437; Chromosome 7. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048840; P:otolith development; IMP:ZFIN. DR Gene3D; 2.60.40.60; -; 5. DR Gene3D; 4.10.900.10; -; 1. DR InterPro; IPR002126; Cadherin. DR InterPro; IPR015919; Cadherin-like. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR000233; Cadherin_cytoplasmic-dom. DR InterPro; IPR027397; Catenin_binding_dom. DR Pfam; PF00028; Cadherin; 5. DR Pfam; PF01049; Cadherin_C; 1. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 5. DR SUPFAM; SSF49313; SSF49313; 5. DR PROSITE; PS00232; CADHERIN_1; 3. DR PROSITE; PS50268; CADHERIN_2; 5. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|RuleBase:RU000484, KW ECO:0000256|SAAS:SAAS00004594}; KW Cell adhesion {ECO:0000256|RuleBase:RU003318, KW ECO:0000256|SAAS:SAAS00004619}; KW Cell membrane {ECO:0000256|SAAS:SAAS00004604}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAAS:SAAS00004615}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00004601}; KW Transmembrane {ECO:0000256|RuleBase:RU003318, KW ECO:0000256|SAAS:SAAS00004589}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00004616}. SQ SEQUENCE 800 AA; 88933 MW; 25B84ABE5598810B CRC64; MWEGLRLQVF FLCLGAALWS AAAAATHRGS GPRERGHRRH LSLHRHRERG KEGQVLHRSK RGWVWNQFFV IEEYTGPDPV LVGRLHSDVD SGDGNIKYIL SGEGAGTIFV IDDKTGNIHA TKTLDREEQA QYTLTAQAVA RDTNKPLEPP SEFIVKVQDI NDNPPEFLHG PYYARVAEMS NVGTSVIKVT ATDADDPTYG NSARLVYSIL QGQPYFSVEP QTGIIRTALP NMDREARQEY DVVIQAKDMG GHMGGLSGTT QVKITLTDVN DNPPKFAQGV YAMAVSEDKV PGEEVGRLKA RDPDLAENGL VDYRILEGDG MNYFEITKDS ETQEAVIKLK KPVDFETKRS YTLKVEATNT HVDPRFIAWG PYKDTTIVKI SVEDADEPPT FMAPSYNFEV EENAPAGTLV GRVHAKDTDM MNNPIRYMIP HYTDLEEFFT INPEDGIIKT TRPLDREAQA WHNISVSATE IGGHHQDAKV RVNIKVKDVN DNAPEFATQN EVLVCENVNP GKLIETVSAT DKDEMAHRQH FHFSLAPEVA NNHSFSLKDN RDSTASIFVI RKGFSRMTQD IYHLPIEIND NGVPPMSSTN TLIIRVCSCD SKDTILSCNV EPFILTAGLS TGALIAILAC IVILLAIVVL FVALRRQKKE PLIVFEEEDI RENIITYDDE GGGEEDTEAF DIATLQNPDG ANGFLPRKDM KPELQYGMRP GLRPIGNSVD VDDFIKTRIS DADNDPTAPP YDSIQIYGYE GRGSIAGSLS SLESVTTDSD LDYDYLQSWG PRFKKLADLY GTKDSVDDNS //