ID B3DGG4_DANRE Unreviewed; 800 AA. AC B3DGG4; A0A286Y9J7; B3DGH9; DT 22-JUL-2008, integrated into UniProtKB/TrEMBL. DT 22-JUL-2008, sequence version 1. DT 29-MAY-2024, entry version 121. DE SubName: Full=Cadherin 11, osteoblast {ECO:0000313|EMBL:AAI63442.1}; DE SubName: Full=Cadherin 11, type 2, OB-cadherin (osteoblast) {ECO:0000313|Ensembl:ENSDARP00000006449}; DE SubName: Full=Cadherin-11 isoform X1 {ECO:0000313|RefSeq:XP_005166503.1, ECO:0000313|RefSeq:XP_021333066.1}; DE SubName: Full=Cadherin-11 precursor {ECO:0000313|RefSeq:NP_571289.1}; DE SubName: Full=Cdh11 protein {ECO:0000313|EMBL:AAI62403.1}; GN Name=cdh11 {ECO:0000313|EMBL:AAI62403.1, GN ECO:0000313|Ensembl:ENSDARP00000006449, GN ECO:0000313|RefSeq:NP_571289.1, ECO:0000313|RefSeq:XP_005166503.1, GN ECO:0000313|RefSeq:XP_021333066.1, ECO:0000313|RefSeq:XP_021333067.1, GN ECO:0000313|ZFIN:ZDB-GENE-980526-170}; GN Synonyms=cdhvn {ECO:0000313|RefSeq:NP_571289.1, GN ECO:0000313|RefSeq:XP_005166503.1, ECO:0000313|RefSeq:XP_021333066.1, GN ECO:0000313|RefSeq:XP_021333067.1}, vnc GN {ECO:0000313|RefSeq:XP_005166503.1, GN ECO:0000313|RefSeq:XP_021333066.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62403.1}; RN [1] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=8725279; RX DOI=10.1002/(SICI)1097-0177(199606)206:2<121::AID-AJA1>3.0.CO;2-K; RA Franklin J.I., Sargent T.D.; RT "Ventral neural cadherin, a novel cadherin expressed in a subset of neural RT tissues in the zebrafish embryo."; RL Dev. Dyn. 206:121-130(1996). RN [2] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14648850; RA Liu Q., Kerstetter A.E., Azodi E., Marrs J.A.; RT "Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral RT limb bud and fin of the developing zebrafish."; RL Dev. Dyn. 228:734-739(2003). RN [3] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12799081; RA Novince Z.M., Azodi E., Marrs J.A., Raymond P.A., Liu Q.; RT "Cadherin expression in the inner ear of developing zebrafish."; RL Gene Expr. Patterns 3:337-339(2003). RN [4] {ECO:0000313|EMBL:AAI62403.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19582870; RA Clendenon S.G., Shah B., Miller C.A., Schmeisser G., Walter A., RA Gattone VH 2.n.d., Barald K.F., Liu Q., Marrs J.A.; RT "Cadherin-11 controls otolith assembly: evidence for extracellular cadherin RT activity."; RL Dev. Dyn. 238:1909-1922(2009). RN [6] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=20553708; RA Rhodes J.M., Bentley F.K., Print C.G., Dorsett D., Misulovin Z., RA Dickinson E.J., Crosier K.E., Crosier P.S., Horsfield J.A.; RT "Positive regulation of c-Myc by cohesin is direct, and evolutionarily RT conserved."; RL Dev. Biol. 344:637-649(2010). RN [7] {ECO:0000313|Ensembl:ENSDARP00000006449} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000006449}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [8] {ECO:0000313|Ensembl:ENSDARP00000006449, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000006449, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [9] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26908177; RA Bugel S.M., Wehmas L.C., La Du J.K., Tanguay R.L.; RT "Phenotype anchoring in zebrafish reveals a potential role for matrix RT metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium."; RL Toxicol. Appl. Pharmacol. 296:31-41(2016). RN [10] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28705894; RA Askary A., Xu P., Barske L., Bay M., Bump P., Balczerski B., RA Bonaguidi M.A., Crump J.G.; RT "Genome-wide analysis of facial skeletal regionalization in zebrafish."; RL Development 144:2994-3005(2017). RN [11] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [12] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29488319; RA Kindt L.M., Coughlin A.R., Perosino T.R., Ersfeld H.N., Hampton M., RA Liang J.O.; RT "Identification of transcripts potentially involved in neural tube closure RT using RNA sequencing."; RL Genesis 56:e23096-e23096(2018). RN [13] {ECO:0000313|RefSeq:NP_571289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29700229; RA Wagner D.E., Weinreb C., Collins Z.M., Briggs J.A., Megason S.G., RA Klein A.M.; RT "Single-cell mapping of gene expression landscapes and lineage in the RT zebrafish embryo."; RL Science 360:981-987(2018). RN [14] {ECO:0000313|Ensembl:ENSDARP00000151942} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000143868}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. RN [15] {ECO:0000313|RefSeq:NP_571289.1, ECO:0000313|RefSeq:XP_005166503.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005166503.1, RC ECO:0000313|RefSeq:XP_021333066.1}; RG RefSeq; RL Submitted (FEB-2024) to UniProtKB. CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. CC {ECO:0000256|RuleBase:RU004357}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251, CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CT025913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC162388; AAI62388.1; -; mRNA. DR EMBL; BC162403; AAI62403.1; -; mRNA. DR EMBL; BC163442; AAI63442.1; -; mRNA. DR RefSeq; NP_571289.1; NM_131214.1. DR RefSeq; XP_005166503.1; XM_005166446.4. DR RefSeq; XP_021333066.1; XM_021477391.1. DR RefSeq; XP_021333067.1; XM_021477392.1. DR STRING; 7955.ENSDARP00000006449; -. DR PaxDb; 7955-ENSDARP00000006449; -. DR Ensembl; ENSDART00000002279.8; ENSDARP00000006449.5; ENSDARG00000021442.10. DR Ensembl; ENSDART00000174592.2; ENSDARP00000143868.1; ENSDARG00000021442.10. DR Ensembl; ENSDART00000179758.1; ENSDARP00000153918.1; ENSDARG00000021442.10. DR Ensembl; ENSDART00000183602.1; ENSDARP00000151942.1; ENSDARG00000021442.10. DR GeneID; 30461; -. DR KEGG; dre:30461; -. DR AGR; ZFIN:ZDB-GENE-980526-170; -. DR CTD; 1009; -. DR ZFIN; ZDB-GENE-980526-170; cdh11. DR eggNOG; KOG3594; Eukaryota. DR HOGENOM; CLU_005284_3_1_1; -. DR OMA; ERYFVIN; -. DR OrthoDB; 3667774at2759; -. DR TreeFam; TF329887; -. DR Reactome; R-DRE-418990; Adherens junctions interactions. DR Proteomes; UP000000437; Chromosome 7. DR Bgee; ENSDARG00000021442; Expressed in spleen and 28 other cell types or tissues. DR GO; GO:0005912; C:adherens junction; IBA:GO_Central. DR GO; GO:0016342; C:catenin complex; IBA:GO_Central. DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central. DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central. DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central. DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central. DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central. DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central. DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central. DR GO; GO:0009790; P:embryo development; IEA:UniProt. DR GO; GO:0060429; P:epithelium development; IEA:UniProt. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048840; P:otolith development; IMP:ZFIN. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN. DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:ZFIN. DR CDD; cd11304; Cadherin_repeat; 5. DR Gene3D; 2.60.40.60; Cadherins; 5. DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1. DR InterPro; IPR039808; Cadherin. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR000233; Cadherin_Y-type_LIR. DR InterPro; IPR027397; Catenin-bd_sf. DR PANTHER; PTHR24027:SF85; CADHERIN-11; 1. DR PANTHER; PTHR24027; CADHERIN-23; 1. DR Pfam; PF01049; CADH_Y-type_LIR; 1. DR Pfam; PF00028; Cadherin; 5. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 5. DR SUPFAM; SSF49313; Cadherin-like; 5. DR PROSITE; PS00232; CADHERIN_1; 2. DR PROSITE; PS50268; CADHERIN_2; 5. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE- KW ProRule:PRU00043}; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889, KW ECO:0000256|RuleBase:RU003318}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_571289.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003318}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..800 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_571289.1" FT /id="PRO_5035035572" FT TRANSMEM 613..644 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 87..167 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 168..276 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 277..391 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 392..496 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 496..614 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT REGION 27..52 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 32..46 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 800 AA; 88933 MW; 25B84ABE5598810B CRC64; MWEGLRLQVF FLCLGAALWS AAAAATHRGS GPRERGHRRH LSLHRHRERG KEGQVLHRSK RGWVWNQFFV IEEYTGPDPV LVGRLHSDVD SGDGNIKYIL SGEGAGTIFV IDDKTGNIHA TKTLDREEQA QYTLTAQAVA RDTNKPLEPP SEFIVKVQDI NDNPPEFLHG PYYARVAEMS NVGTSVIKVT ATDADDPTYG NSARLVYSIL QGQPYFSVEP QTGIIRTALP NMDREARQEY DVVIQAKDMG GHMGGLSGTT QVKITLTDVN DNPPKFAQGV YAMAVSEDKV PGEEVGRLKA RDPDLAENGL VDYRILEGDG MNYFEITKDS ETQEAVIKLK KPVDFETKRS YTLKVEATNT HVDPRFIAWG PYKDTTIVKI SVEDADEPPT FMAPSYNFEV EENAPAGTLV GRVHAKDTDM MNNPIRYMIP HYTDLEEFFT INPEDGIIKT TRPLDREAQA WHNISVSATE IGGHHQDAKV RVNIKVKDVN DNAPEFATQN EVLVCENVNP GKLIETVSAT DKDEMAHRQH FHFSLAPEVA NNHSFSLKDN RDSTASIFVI RKGFSRMTQD IYHLPIEIND NGVPPMSSTN TLIIRVCSCD SKDTILSCNV EPFILTAGLS TGALIAILAC IVILLAIVVL FVALRRQKKE PLIVFEEEDI RENIITYDDE GGGEEDTEAF DIATLQNPDG ANGFLPRKDM KPELQYGMRP GLRPIGNSVD VDDFIKTRIS DADNDPTAPP YDSIQIYGYE GRGSIAGSLS SLESVTTDSD LDYDYLQSWG PRFKKLADLY GTKDSVDDNS //