ID YTM1_PYRTR Reviewed; 460 AA. AC B2VZH2; DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-2008, sequence version 1. DT 29-SEP-2021, entry version 66. DE RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029}; GN Name=ytm1; ORFNames=PTRG_02812; OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) OS (Drechslera tritici-repentis). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes; OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; OC Pyrenophora. OX NCBI_TaxID=426418; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Pt-1C-BFP; RX PubMed=23316438; DOI=10.1534/g3.112.004044; RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S., RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.; RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici- RT repentis, reveals transduplication and the impact of repeat elements on RT pathogenicity and population divergence."; RL G3 (Bethesda) 3:41-63(2013). CC -!- FUNCTION: Component of the NOP7 complex, which is required for CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}. CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and CC ytm1. The complex is held together by erb1, which interacts with nop7 CC via its N-terminal domain and with ytm1 via a high-affinity interaction CC between the seven-bladed beta-propeller domains of the 2 proteins. The CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL CC domain) with mdn1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP- CC Rule:MF_03029}. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP- CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}. CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family. CC {ECO:0000255|HAMAP-Rule:MF_03029}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS231616; EDU45335.1; -; Genomic_DNA. DR RefSeq; XP_001933145.1; XM_001933110.1. DR SMR; B2VZH2; -. DR STRING; 45151.EDU45335; -. DR EnsemblFungi; EDU45335; EDU45335; PTRG_02812. DR GeneID; 6341035; -. DR eggNOG; KOG0313; Eukaryota. DR HOGENOM; CLU_000288_57_0_1; -. DR InParanoid; B2VZH2; -. DR OMA; DARTNQG; -. DR OrthoDB; 1540178at2759; -. DR Proteomes; UP000001471; Unassembled WGS sequence. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule. DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule. DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule. DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule. DR Gene3D; 2.130.10.10; -; 1. DR HAMAP; MF_03029; WDR12; 1. DR InterPro; IPR020472; G-protein_beta_WD-40_rep. DR InterPro; IPR012972; NLE. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR028599; WDR12/Ytm1. DR Pfam; PF08154; NLE; 1. DR Pfam; PF00400; WD40; 3. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 1. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 3: Inferred from homology; KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; KW WD repeat. FT CHAIN 1..460 FT /note="Ribosome biogenesis protein ytm1" FT /id="PRO_0000369600" FT REPEAT 105..148 FT /note="WD 1" FT REPEAT 155..193 FT /note="WD 2" FT REPEAT 200..239 FT /note="WD 3" FT REPEAT 275..315 FT /note="WD 4" FT REPEAT 317..356 FT /note="WD 5" FT REPEAT 362..402 FT /note="WD 6" FT REPEAT 427..460 FT /note="WD 7" FT REGION 10..93 FT /note="Ubiquitin-like (UBL) domain" FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029" FT REGION 239..264 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 239..254 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 460 AA; 49820 MW; 1D55655DDCEB3F51 CRC64; MDVDAAETKV QIRLTTRDSS LQISEEPNVL LVQTSLTRHK LSTLVNELLH RGDETRIPFD ILINGEFLRT TIDEFLTKNG INAESTLDVE YTRALVPPLN VTSFEHDDWV SAVDVLSGVQ SGQERILSAS YDGLVRVWNT SGDVLATSEA PNNGGRITSL KTAKWLSEKK MVAAGLDNNV RVYKYDDDAR TIITALELVN HRWGVEDVAV HAPSNRILSA SSDTTISLFS SNAKENPVAP ANLLPSSSAA SNKRQKLSKP DRTVPARGAL ATFTGHSSPV SSVIFKPDDA TVAYSASHDH TLKTWDLPTS TCVDTRTTGH SLLSLCAIPS RNLLATGTSA RHITLIDPRA SATQISVMTL RGHKNGVVSL DTDPSSEHNL ASASHDGTVQ IWDLRNVSTG SQIGEGMQGE SVYTIYRQGR DTSKSHGEGT KVFSVRWDRA VGIVSGGEDK RVQINRALGS //