ID YTM1_PYRTR Reviewed; 460 AA. AC B2VZH2; DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-2008, sequence version 1. DT 25-OCT-2017, entry version 51. DE RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029}; GN Name=ytm1; ORFNames=PTRG_02812; OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot OS fungus) (Drechslera tritici-repentis). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae; OC Pleosporaceae; Pyrenophora. OX NCBI_TaxID=426418; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Pt-1C-BFP; RX PubMed=23316438; DOI=10.1534/g3.112.004044; RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., RA Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., RA Schackwitz W., Schwartz D.C., Spatafora J.W., Turgeon B.G., RA Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., RA Ciuffetti L.M.; RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora RT tritici-repentis, reveals transduplication and the impact of repeat RT elements on pathogenicity and population divergence."; RL G3 (Bethesda) 3:41-63(2013). CC -!- FUNCTION: Component of the NOP7 complex, which is required for CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the CC 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}. CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and CC ytm1. The complex is held together by erb1, which interacts with CC nop7 via its N-terminal domain and with ytm1 via a high-affinity CC interaction between the seven-bladed beta-propeller domains of the CC 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. CC Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain). CC {ECO:0000255|HAMAP-Rule:MF_03029}. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP- CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP- CC Rule:MF_03029}. CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family. CC {ECO:0000255|HAMAP-Rule:MF_03029}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS231616; EDU45335.1; -; Genomic_DNA. DR RefSeq; XP_001933145.1; XM_001933110.1. DR ProteinModelPortal; B2VZH2; -. DR SMR; B2VZH2; -. DR STRING; 426418.XP_001933145.1; -. DR EnsemblFungi; EDU45335; EDU45335; PTRG_02812. DR GeneID; 6341035; -. DR eggNOG; KOG0313; Eukaryota. DR eggNOG; ENOG410XPW5; LUCA. DR InParanoid; B2VZH2; -. DR OrthoDB; EOG092C3UHD; -. DR Proteomes; UP000001471; Unassembled WGS sequence. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. DR HAMAP; MF_03029; WDR12; 1. DR InterPro; IPR020472; G-protein_beta_WD-40_rep. DR InterPro; IPR012972; NLE. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR017986; WD40_repeat_dom. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR028599; WDR12/Ytm1. DR Pfam; PF08154; NLE; 1. DR Pfam; PF00400; WD40; 3. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 2. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 3: Inferred from homology; KW Complete proteome; Nucleus; Reference proteome; Repeat; KW Ribosome biogenesis; rRNA processing; WD repeat. FT CHAIN 1 460 Ribosome biogenesis protein ytm1. FT /FTId=PRO_0000369600. FT REPEAT 105 148 WD 1. FT REPEAT 155 193 WD 2. FT REPEAT 200 239 WD 3. FT REPEAT 275 315 WD 4. FT REPEAT 317 356 WD 5. FT REPEAT 362 402 WD 6. FT REPEAT 427 460 WD 7. FT REGION 10 93 Ubiquitin-like (UBL) domain. FT {ECO:0000255|HAMAP-Rule:MF_03029}. SQ SEQUENCE 460 AA; 49820 MW; 1D55655DDCEB3F51 CRC64; MDVDAAETKV QIRLTTRDSS LQISEEPNVL LVQTSLTRHK LSTLVNELLH RGDETRIPFD ILINGEFLRT TIDEFLTKNG INAESTLDVE YTRALVPPLN VTSFEHDDWV SAVDVLSGVQ SGQERILSAS YDGLVRVWNT SGDVLATSEA PNNGGRITSL KTAKWLSEKK MVAAGLDNNV RVYKYDDDAR TIITALELVN HRWGVEDVAV HAPSNRILSA SSDTTISLFS SNAKENPVAP ANLLPSSSAA SNKRQKLSKP DRTVPARGAL ATFTGHSSPV SSVIFKPDDA TVAYSASHDH TLKTWDLPTS TCVDTRTTGH SLLSLCAIPS RNLLATGTSA RHITLIDPRA SATQISVMTL RGHKNGVVSL DTDPSSEHNL ASASHDGTVQ IWDLRNVSTG SQIGEGMQGE SVYTIYRQGR DTSKSHGEGT KVFSVRWDRA VGIVSGGEDK RVQINRALGS //