ID B2UQE3_AKKM8 Unreviewed; 277 AA. AC B2UQE3; DT 01-JUL-2008, integrated into UniProtKB/TrEMBL. DT 01-JUL-2008, sequence version 1. DT 10-FEB-2009, entry version 7. DE SubName: Full=Apurinic endonuclease Apn1; DE EC=3.1.21.2; GN OrderedLocusNames=Amuc_0845; OS Akkermansia muciniphila (strain ATCC BAA-835). OC Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales; OC Verrucomicrobiaceae; Akkermansia. OX NCBI_TaxID=349741; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., RA Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., RA Ivanova N., Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., RA de Vos W.M., Richardson P.; RT "Complete sequence of Akkermansia muciniphila ATCC BAA-835."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'- CC phosphooligonucleotide end-products. CC -!- COFACTOR: Binds 3 zinc ions. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001071; ACD04678.1; -; Genomic_DNA. DR RefSeq; YP_001877459.1; -. DR GeneID; 6274324; -. DR GenomeReviews; CP001071_GR; Amuc_0845. DR KEGG; amu:Amuc_0845; -. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0008833; F:deoxyribonuclease IV (phage-T4-induced) act...; IEA:EC. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR InterPro; IPR001719; AP_endonuc_F2. DR InterPro; IPR013022; Xyl_isomerase-like_TIM-brl. DR InterPro; IPR012307; Xyl_isomerase-typ_TIM-brl. DR Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1. DR PANTHER; PTHR21445; AP_endnuclease2; 1. DR Pfam; PF01261; AP_endonuc_2; 1. DR SMART; SM00518; AP2Ec; 1. DR TIGRFAMs; TIGR00587; nfo; 1. DR PROSITE; PS00730; AP_NUCLEASE_F2_2; 1. PE 4: Predicted; KW Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; KW Metal-binding; Nuclease; Zinc. SQ SEQUENCE 277 AA; 30780 MW; 0AB7EB291259D263 CRC64; MPYIGCHLSS AKGYEAMGRV ALSIGANTFQ FFTRNPRGSK AKAIDEQDIA RFLELARNNG FGTLLAHAPY TLNPCSADPS VARFAAQVLK EDLELMEHLP GNLYNFHPGC HVGQGVEKGI ELVADQLNDV LSPEQKTIVL LETMSGKGSE VGRTFEELAA IMERVDLKDK LGVCLDTCHV YSAGYDIVNR LDSVLEHFDA VLGLERLRAI HLNDSMTPFS SFKDRHETIG KGSLGEQAFI NIINHPVLRE LPFFLETPRD DAGHGEEITW LKEHYRN //